GLYCOSURIA FROM CHILL 299 



potassium and calcium salts. 75 Injection of concentrated 

 salt solutions produces pronounced hyperglycaemia, but there 

 is also induced an alteration in the renal efficiency (probably 

 due to change of the osmotic pressure relations) and the 

 glycosuria may fail to appear. 76 



Glycosuria from Chill. ' ' Eef rigeration glycosuria" 

 should finally be briefly mentioned, observed first by Bohm 

 and Hoffmann and later by Araki when they reduced the 

 body temperature of warm blooded animals to a low level by 

 cold baths, snow packs, etc. Grlassner 77 was in the same way 

 able to recognize glycosuria in individuals who had at- 

 tempted suicide by jumping into cold water. Whether the 

 coincident occurrence of lactic acid, which may be regarded 

 as due to the combined influence of oxygen impoverishment 

 and increased muscular activity, has any direct connection 

 with the glycosuria, may remain undecided. Even in frogs 

 a glycosuria may be induced by exposure to intense cold, 

 interpreted by M. Lowit 78 on the hypothesis that the oxida- 

 tion processes are interfered with, and that as a result there 

 may ensue disturbance in the consumption of sugar, altera- 

 tion of the renal permeability and glycosuria. 



n M. H. Fischer, Pfluger's Arch., 109, 1, 1905, and earlier contributions; 

 O. H. Brown, Amer. Jour, of Physiol., 10, 378, 1904; T. C. Burnett (Univ. of 

 California), Jour, of Biol. Chem., 4, 57; 5, 351, 1908. 



76 G. Wilenko (Lemberg), Arch. f. exper. Pathol., 66, 143, 1911. 



77 K. Glassner, Wiener klin. Wochenschr., 1906, p. 30. 



78 M. Lowit, Arch. f. exper. Pathol., 60, 1908. 



