302 ADRENALS IN CARBOHYDRATE METABOLISM 



influence of hunger, physical exertion, cold or earlier injec- 

 tions of suprarenin, phloridzin, etc., glycosuria may fail to 

 appear. In a previous lecture occasion was taken to call 

 attention to the fact that the economy is abundantly provided 

 with means to maintain the sugar in the blood at constant 

 level and that if the carbohydrate elements are used up it is 

 in position to build sugar de novo from protein. An excel- 

 lent example of this process is afforded in recent studies of 

 L. Pollak, who has been able to show in the Pharmacological 

 Institute in Vienna that in starving rabbits which have had 

 their glycogen removed by strychnine convulsions, repeated 

 administration of suprarenin in increasing dosage may in- 

 duce an accumulation of glycogen in the liver, of proportions 

 elsewhere seen only in animals fed upon carbohydrates. It 

 is of interest to note that the muscles, which usually (as the 

 most important physiological sites of glycogen consump- 

 tion) have a tendency to attract the carbohydrate stores from 

 the liver for their own purposes, are under these circum- 

 stances entirely or almost entirely free of glycogen. 5 



Dependence of Adrenin Glycosuria Upon the Renal 

 Function. Suprarenin diabetes should undoubtedly be 

 classed from its essential character among the glycosurias 

 accompanied by hyperglycaemia. Whether it is possible to 

 actually find at a given moment after adrenin application 

 that the level of sugar in the blood is distinctly raised, de- 

 pends upon the precision and readiness with which the kid- 

 ney affords passage of a surplus of sugar from the blood into 

 the urine. Here, too, studies in the Vienna Pharmacologi- 

 cal Institute have led to important conclusions. Thus it 

 has been proved that in rabbits a proportion of 0.15 to 0.25 

 per cent, of sugar in the blood will give rise to glycosuria 

 only in case a marked diuresis coexists (as after use of 



6 L. Pollak (Pharmakol. Instit., Vienna), Arch. f. exper. Pathol., 61, 166, 

 1909; cf. therein Literature: Doyen and Kareff, Gatin-Gruzewska, Agadschi- 

 ananz, et al.; W. B. Dmmmond and D. Noel Paton, Jour, of Physiol., 31, 98, 

 1904. 



