ADRENIN GLYCOSURIA 303 



caffein) ; without the diuresis the glycosuria remains in 

 abeyance. If the proportion of sugar in the blood exceeds 

 0.25 per cent, there is no longer necessity for the diuresis to 

 put the glycosuria in operation. After repeated subcuta- 

 neous injections of adrenin, however, the kidneys may 

 acquire a sort of tolerance, making it possible that glyco- 

 suria will not be manifested even when the proportion of 

 sugar in the blood becomes very high. 6 While under certain 

 conditions even with approximately normal proportions of 

 sugar in the blood a glycosuria can be caused by certain 

 nephrotoxines like chromium, uranium or corrosive sub- 

 limate (" renal diabetes "), there are other renal lesions (as 

 temporary ligation of the renal artery), according to 

 Ellinger and Seelig, 7 which promptly inhibit the glycosuria 

 caused by adrenalin. There is scarcely any doubt that some 

 alteration of the renal circulation is directly concerned with 

 the suppression of adrenin glycosuria, so often seen after 

 injection of lymphagogues (extract of crab meat, 8 hirudin, 9 

 and Witte's peptone 10 ), in infectious diseases, 11 and experi- 

 mentally produced fever, 12 after extirpation of both 

 adrenals, 13 and other severe operative interferences, after 

 peritoneal irritations u (which may be produced by injec- 

 tion of trypsin or pancreatic juice, vide supra, p. 262), after 

 injections of calcium chloride, 15 etc. 



Occasion was taken in a previous lecture to point out that 

 it is entirely reasonable to believe that passage of adrenin 

 from the adrenal medulla into the circulating blood takes 



L. Pollak, 1. c., p. 157. 



7 A. Ellinger and Seelig, Miinchener med. Wochenschr., 1905, No. 11. 



8 A. Biedl and Offer, Wiener klin. Wochenschr., 1907, 1530. 



* Mikulicich, 1. c. 



10 K. Glassner, and E. Pick, Zeitschr. f. exper. Pathol., 6, 1909. 

 n G. Ghedini and G. Mascerpa, Folia Clinica, 2, H. 3, cited in Centralbl. f. d. 

 ges. Biol., 11, No. 2508. 



M Aronsohn, Virehow's Arch., 174, 383, 1903. 



13 J. Gautrelet and L. Thomas, C. R. Soc. de Biol., 66, 798, 1909. 

 "0. v. Furth and C. Schwarz, Biochem. Zeitschr., 31, 113, 1911. 

 "F. Schrank, Zeitschr. f. klin. Med., 67, 230, 1908. 



