332 SUGAR DESTRUCTION IN THE ECONOMY 



eludes that the statements of Stoklasa and his collaborators 

 have not been controverted, and believes that we cannot 

 deny the possibility that an alcoholic fermentation can exist 

 in animal tissues as well as in plant tissues in anaerobic 

 respiration. 



Here again is an example of how differently a given 

 situation may strike the minds of different individuals. 



The same impression will be aroused when we attempt 

 to discuss what is thought to be known of the glycolytic 

 power of ground-up tissues and the expressed juices of 

 tissues. 



Cpknheim's Pancreas-Muscle Experiment. In view of 

 the importance to be attributed to the pancreas in carbohy- 

 drate metabolism since the discovery of pancreatic diabetes, 

 it was desirable to determine whether a special extracorpor- 

 eal glycolytic power is inherent to the pancreas. Otto Cohn- 

 heim believes that this may be answered affirmatively, in 

 the sense that the muscles contain a glycolytic ferment which 

 owes its activation to the pancreas. The "pancreatic acti- 

 vator " is believed to be a thermostable substance, soluble 

 in dilute alcohol, the effect of which in increasing amounts 

 is peculiar, first increasing and then diminishing. Cohn- 

 heim compares this last with the phenomena of complement 

 deviation and overfixation in the combined action of 

 amboceptor and complement. In extraction of the glyco- 

 lytic enzyme of the muscle, which is very easily affected by 

 salt solutions, an ice-cold solution of sodium oxalate is re- 

 commended. The quantity present in muscles is believed to 

 be subject to marked variation even in physiological condi- 

 tions ; thus it is supposed that cat muscle is strongly active 

 in glycolysis if the cats have been fed upon milk and sugar, 

 but of little glycolytic power if the animals are fed on fat 

 or fatigued from physical exercise. 12 



12 O. Cohnheim (Heidelberg), Zeitschr. f. physiol. Chem., 39, 396, 1903; 

 42, 402, 1904; 43, 547, 1905; 7/7, 253, 1906. 



