340 SUGAR DESTRUCTION IN THE ECONOMY 



the addition of pancreatic extract restores it. 25 If with 

 these findings we take into account the previously described 

 observations of E. H. Starling (v. sup., p. 256), who ob- 

 served a distinct increase of the amount of sugar used up 

 by artificially perfused hearts of depancreatized animals 

 after addition of pancreatic extract to the perfused blood, 

 we cannot help feeling that the active manifestation of 

 glycolytic power by the corpuscular elements of the blood 

 is no more than an isolated example of what is really a gen- 

 eral rule, that perhaps every living cell is capable of decom- 

 posing sugar and requires in carrying out this function the 

 combined influence of an activator secreted into the 

 circulation by the pancreas. 



However, that the formed elements of the blood, espe- 

 cially the leucocytes, are directly connected with the glyco- 

 lytic processes in the blood cannot well be doubted from the 

 uniform confirmation of numerous investigators. Thus 

 Lepine and Boulud refer glycolysis in the blood (in their 

 estimation not only the " immediate " but the "virtuelle" 

 haemie sugar as well should be included) to the colorless 

 blood cells which in this point are of decidedly more impor- 

 tance than the red cells. 26 The observations of Nadina 

 Sieber upon a glycolytic ferment in the blood fibrin may 

 perhaps be related with the white corpuscles in the fibrin. 27 

 P. Rona and A. Doblin look on the observation that even a 

 sparing haemolysis occasioned by addition of water will stop 

 glycolysis (while dilution with Ringer's solution or with 

 physiological salt solution has no influence upon it) as favor- 

 ing the idea that sugar catabolism in the blood is surely not 

 a simple oxidation process, being seen even in complete 

 absence of oxygen, and is connected with the integrity of 



28 E. Vandeput (Slosse's Lab., Brussels), Arch, intern, de Physiol., 0, 

 293, 1910; cf. also J. Edelmann (Odessa), Biochem. Zeitschr., 40, 314, 1912. 



96 R. L6pine and Boulud, Jour, de Physiol., 13, 353, 1911; C. R. Soc. de 

 Biol., 60, 901, 1906. 



*N. Sieber (Petersburg), Zeitschr. f. physiol. Chem., 44, 560, 1905. 



