370 DIGESTION AND RESORPTION OF FATS 



by traversing the capillary wall and are taken up in 

 corpuscular form, as are other suspended particles in cer- 

 tain cell groups, by the tissues, especially the liver, spleen 

 and bone-marrow. 54 



Masking of the Fat in the Blood. Information obtained 

 in another way indicates, however, that in the disappearance 

 of the fat from the blood that there are processes of a very 

 different character which we must also consider. W. Conn- 

 stein and Michaelis came to the conclusion that there exists 

 a lipolytic function of the blood. If, to be specific, an 

 emulsion of fat be mixed with blood and air conducted 

 through it, one will notice an appreciable loss in the ethereal 

 extract. That an ester-splitting ferment discovered by 

 Hanriot in the blood has no part at all in the disappearance 

 of the fat from the blood was shown by careful studies long 

 ago by Arthus, and also by Doyon and Morel. The latter 

 authors were able to show that the reduction in the ethereal 

 extract obtained from blood containing fat does not coincide 

 in the least with cleavage of the fat into fatty acids and 

 glycerol. 55 



Recent investigations, among which those of Mansfeld, 56 

 of Budapesth, are prominent, have shown the unexpected 

 fact that in this puzzling disappearance of the fat from the 

 blood (aside from the above mentioned escape of the blood 

 dust particles from the blood vessels through the walls of 

 the capillaries into the cells) we are not dealing with either 

 a cleavage process or with one of destruction, but rather 

 with a process of masking. It was mentioned above that fat 

 in contact with albumin (as shown in Fano's laboratory) 



M S. Biondi and A. Neumann, Wiener klin. Wochenschr., 1910, 734; 

 E. Nobel (S. Exner's Lab., Vienna), Pfliiger's Arch., 134, 436, 1910; J. Leva 

 (Berlin), Berliner klin. Wochenschr., 1909, 961. 



65 Connstein and Michaelis, Hamburger, Weigert, Arthus, Doyon and Morel ; 

 cf. the Literature: W. Connstein, Ergebn. d. Physiol., 3', 210-223, 1904; cf. 

 also the statements of P. Rona and L. Michaelis, Biochem. Zeitschr., 31, 345, 

 1910, as to the existence of a tributyrin-splitting ferment in the blood. 



M G. Mansfeld (Pharmacol. Instit., Budapesth), Magyar Orvosi Arch., 9, 

 cited in Jahresber. f. Tierchem., 1908, 84; Pfliiger's Arch., 129, 46, 63, 1909. 



