PASSAGE OF FAT OUT OF BLOOD STREAM 375 



solved state. The liver undoubtedly performs an important 

 role in working up the fat which passes out of the circulat- 

 ing blood. 68 Observations of K. Glassner and G-. Singer 

 on animals with biliary fistulas indicate that the fat of the 

 food passes to the liver by way of the blood, is fixed there 

 for a brief period and may also be in part excreted in the 

 bile. 69 



Passage of the Fat Out of the Blood Stream. But when 

 it is realized that in pathological lipaemia large quantities of 

 fat continue in concentration in the blood, the logical con- 

 clusion must necessarily be that for some reason or other 

 the fat must be hindered in its passage out of the circulating 

 blood. There is not the least basis for accepting the idea 

 that the parenchymatous tissues because of loss of oxidizing 

 power have been deprived of their ability to consume fat in 

 their normal manner. As Magnus-Levy properly suggests, 

 it is impossible to consider anything except some added diffi- 

 culty of passage of the fat out of the capillaries, either from 

 change in the permeability of the capillary walls or from 

 delay in the occurrence of the changes which are necessary 

 in the fat itself in order to enable it to pass through the 

 capillary wall. 70 What the nature of such changes is it is 

 impossible to say at present. 



Brief reference may here be made to the question as to 

 what conditions are required for the passage of the fat from 

 the blood into the urine. There is no doubt that in condi- 

 tions of concentration of fat in the blood small amounts of 

 the former may pass over into the urine. 71 Both lipuria 

 and albuminuria have been induced coincidently by infusion 

 of cream intravenously in the dog, the fat appearing in the 

 urine as a persistent cloud-like emulsion. 72 Massive occur- 



88 F. Ramond, Jour, de Physiol., 7, 245, 1905. 



69 K. Glassner and G. Singer (E. Freund's Lab., Vienna), Med. Klinik, 

 1909, No. 51. 



T0 A. Magnus-Levy and L. F. Meyer, 1. c., p. 465. 



71 B. Schondorff (Physiol. Instit., Bonn), Pfliiger's Arch., 117, 291, 1907; 

 cf. therein the Literature. 



"A. Magnus-Levy and L. F. Meyer. 1. c.. p. 469. 



