DEPOSIT OF FOREIGN FAT 381 



which was above mentioned between glycogen and fat. 4 

 Pfliiger found in a dog which had been fed solely upon large 

 quantities of fat for a month, that all of the glycogen had 

 been replaced in the liver by fat, which comprised almost 

 half of the dried hepatic substance. 5 From the readiness 

 with which the economy is able to draw upon its fat supply 

 in case of need, it is remarkable with what tenacity a 

 residuum of the fat is retained. According to F. N. Schulz 6 

 the external appearance alone of a starved dog affords no 

 basis for judging the amount of fat in its economy, and mere 

 long continuance of starvation is not sufficient to actually 

 make an animal free of fat. 



Deposit of Foreign Fat. We may now take up more fully 

 the question of the manner in which the economy makes use 

 of the food fat. 



A long series of experiments have proved that the body 

 can lay down foreign types of fat in its own depots. It has 

 been shown that oil of rape, linseed oil, oil of sesame, mutton 

 suet and cow's butter are not only deposited in the system, 

 but that foreign types of fat may also find their way into 

 milk, eggs and the coccygeal secretion of birds. 7 Iodized 

 and bromized fats can also be laid down in the body, as 

 shown by the studies of Winternitz, Coronedi and others. 8 



For a long time no more doubt has been entertained as 



4 A. Magnus-Levy, Noorden's Handb. d. Path. d. Stoffw., 2d ed., 1, 177, 

 1906, regards the antagonism between glycogen and fat accumulation in the 

 liver as not an absolute one; he states that he has frequently found in typical 

 examples of fois gras of Strassburg geese very large deposits of glycogen along 

 with enormous quantities of fat. 



6 Cf. also Pfliiger and E. Junkersdorf, ibid., 131, 225, 1910. 

 *F. N. Schulz (Pfliiger's Lab.), Pfliiger's Arch, 66, 145, 1897. 



7 Radziejewski, Lebedeff, J. Munk, Leube, G. Rosenfeld, Winternitz, Cas- 

 pari, Zaitschek, Rohmann, Henriques and Hansen; Literature: G. Rosenfeld, 

 Ergebn. d. Physiol., 1", 673-678, 1902; A. Magnus-Levy, Noorden's Handb. d. 

 Pathol. d. Stoffw., 2d ed., 1, 178, 1906. 



8 G. Coronedi and R. Luzzatto, Arch, di Farmacol., 12, 343, cited in Cen- 

 tralbl. f. Physiol., 21, 122, 1907; cf. G. Coronedi ( Parma ), VIII Intern. Physiol. 

 Congr., Vienna, Sept., 1910; G. Coronedi and F. Dematheis, Boll, della Societa 

 med. di Parma., July, 1911. 



