THE URINE IN INANITION 505 



dered almost free of glycogen by fasting there may take place 

 formation of glycogen de novo. Thus Zuntz observed, in 

 rabbits which had lost almost all their glycogen from com- 

 bined inanition and strychnine convulsions, the reappearance 

 of glycogen at the conclusion of a protracted chloral nar- 

 cosis. 55 After all that has been said of the formation of 

 sugar in connection with phloridzin diabetes and pancreatic 

 diabetes, there is little occasion for surprise in this. Stiles 

 and Graham Lusk observed in a fasting dog poisoned with 

 phloridzin that while the amount of nitrogen eliminated un- 

 derwent diminution the sugar formation fell at the same 



T\ *ifi 



time, thus maintaining unaltered the quotient ^~ 



The Urine in Inanition. The acidosis of inanition is a 

 striking anomaly of metabolism. Eeference to this phe- 

 nomenon has been made above in connection with the acetone 

 bodies, where it was stated that we have every reason to look 

 upon the formation of /3-oxybutyric acid and diacetic acid in 

 the fasting individual as related to the breakdown of fat. 

 The proportion of acetone bodies in inanition urine may at 

 times be very considerable; thus D. Gerhardt and W. 

 Schlesinger found in a case of hysterical vomiting forty 

 grams of oxybutyric acid in the urine in the course of twenty- 

 four hours. The natural result of the abnormal acid produc- 

 tion in the body is an increased elimination of ammonia in the 

 urine; Brugsch observed as much as thirty-five per cent, 

 of ammonia nitrogen. For fuller details in this connection 

 reference may be made to the monograph of C. von 

 Noorden. 57 



A great deal of trouble has been expended upon the analy- 

 sis of inanition urine. From among the discoveries which 

 have invariably rather poorly rewarded the labor expended 

 in this direction, special mention may be made of the observa- 



56 Cf. Literature (N. Zuntz and Vogelius, Nebelthau, Kiilz, Frenzel) ; Th. 

 Brugsch, 1. c., p. 300. 



56 Stiles and Graham Lusk, Amer. Jour, of Physiol., 10, 77, 1903. 



57 C. von Noorden, 1. c., pp. 529-536. 



