INDIVIDUALITY OF HEMOGLOBIN 581 



Hcemochrome and Crystallized Blood Coloring Matter. 

 When these points are kept in mind there is no need to be 

 surprised that the observations made in reference to the 

 red-blood coloring matter are not of a uniformly consistent 

 nature. After Bohr had brought forward the real blood 

 coloring matter, "haemochrome," in contrast to the crystal- 

 lized coloring material obtained from the blood, the cor- 

 rectness of this counterview became the subject of warm 

 discussion. 



Thus Franz Miiller assumed with Bohr "that the color- 

 ing matter of different individuals of the same species and 

 of the same individual at different times may have differ- 

 ent light absorption properties and a varying proportion 

 of iron, and that these variations are particularly appreci- 

 able in conditions of blood regeneration and in pathological 

 states." However even in the crystals produced from the 

 native coloring material it would seem that the specific 

 capacity for oxygen may be as individualized as in case of 

 the blood coloring matter itself and may vary among differ- 

 ent animal species. 5 



Individuality of Hcemoglobin. In contradiction to this 

 position, however, it must be stated that studies by Abder- 

 halden on goose-blood, 6 similar observations in v. Zeynek's 

 laboratory on the blood of sea turtles, 7 and studies in the 

 Heidelberg medical clinic 8 of the blood of healthy and dis- 

 eased human beings, bespeak throughout the individuality 

 of pure haemoglobin. Above all, however, the many studies, 

 carried out with the utmost precision by the recently-de- 

 ceased master of haemoglobin research, G. Hiifner, and the 



B F. Muller, Handb. d. Biochem., 1, 669, 675, 1909; cf. also A. Bernstein 

 and F. Muller, Physiol. Kongress, Heidelberg, 1907, Centralbl. f. Physiol, 21, 

 478, 1907. 



9 E. Abderhalden and F. Medigreceanu, Zeitschr. f. physiol. Chem., 59, 165, 

 1909. 



7 F. Bardachzi (v. Zeynek's Lab., Prague), Zeitschr. f. physiol. Chem., 

 49, 465, 1906. 



8 E. Masing (Med. Clinic of Krehl, Heidelberg), Deutsch. Arch. f. klin. 

 Med., 98, 122, 1909; E. Masing and R. Siebeck, ibid., 99, 130, 1910. 



