622 FEVER 



animals are not exempt as a matter of fact from infectious 

 fever, but are exempt from the hyperthermia of the heat 

 puncture. But as meanwhile it appears from studies of 

 Senator and P. P. Eichter that, even in animals rendered 

 practically free of glycogen by a combination of starvation 

 and strychnine poisoning, the heat puncture remains effec- 

 tive although in a lessened degree, there need be no occasion 

 for entering into the interpretations which have been pro- 

 posed for the former experiments. It is safe to say that 

 there is no form of hyperthermia which is invariably con- 

 nected with an increased accumulation of glycogen in the 

 tissues. 34 



Changes in the Constitution of the Blood Plasma. A 

 characteristic alteration of the blood has been persistently 

 sought for. There are two features, as far as the author 

 sees, which have been brought out: an increase of globulin 

 and an increase of fibrinogen in proportion to the other 

 proteins of the blood (cf. Vol. I of this series, pp. 194 and 

 244, Chemistry of the Tissues). The increase of globulin, 

 which has been observed by a large number of authorities, 35 

 is a feature of inanition conditions of various kinds ; while 

 increase of fibrinogen, according to T. Pf eiffer, is apt to be 

 met especially in infections due to pneumococci and strep- 

 tococci. It apparently goes hand in hand, according to P. T. 

 Miiller, with a fibrinogen enrichment of lymphadenoid tis- 

 sues, especially the bone marrow. Of course the idea is 

 suggested that the ' ' hyperinosis, ' ' or increase in the amount 

 of fibrinogen in the blood, which occasions the ' t crusta phlo- 

 gista" (that well-known coagulation phenomenon of the old 

 physicians), may be connected with an increased produc- 

 tion of fibrinogen in the bone marrow. 



34 Literature upon the Relation of Carbohydrate Metabolism to Fever: 

 F. Kraus, 1. c., pp. 630-634, 1906; A. Magnus-Levy, Handb. d. Biochem., 4', 

 363-364, 1909; I. Wohlgemuth, ibid., 3', 173-174, 1910; P. F. Richter, ibid., 

 4", 125-128, 1910. 



80 Joachim, Langstein and Mayer, Moll, Cavazzuoli; Literature: F. Kraus, 

 1. c., pp. 611-613, and P. F. Richter, 1. c., p. 137. 



