626 FEVER 



dealing with a disturbance of the renal function caused by 

 altered circulatory relations. The author has come to this 

 view on the basis of observations upon reflex influences in- 

 volving the renal capacity which he studied with C. Schwarz 

 (Vol. I of this series, p. 382, Chemistry of the Tissues). In 

 these studies the observers found that a peritoneal irrita- 

 tion produced experimentally by injection of pancreatic tis- 

 sue, oil of turpentine or aleuronat, is caipable of influencing 

 the functional ability of the kidneys in such a manner as to 

 lower in a very striking degree the quantity of dissolved 

 constituents, particularly the sodium chloride, independently 

 of the water elimination. From this the author would 

 assume that a disturbance of circulation induced by the 

 febrile condition may act in very much the same way. 



As may be seen from what has been said above, the hope 

 of more closely approaching the real nature of fever by 

 examination of the metabolic processes has thus far not 

 been fulfilled, and we are forced to return to the start- 

 ing point of our inquiries, and, in connection with the previ- 

 ously described line of thought of Traube, seek an explana- 

 tion of the process in a disturbance of heat regulation. 



It is impossible to consider the development here of the 

 whole physiology and pathology of heat mechanism, 47 and 

 the author feels that he must be satisfied to present only 

 some of the most essential items. 



Chemical and Physical Heat Regulation. Following 

 Rubner's comprehensive studies, it is essential to differ- 

 entiate between chemical and physical heat regulation. 

 While for maintenance of the body heat in case of low 

 external temperature the dominating factor is apparently 



47 Literature upon the Processes of Heat Regulation : 0. Lowy, Ergebn. d. 

 Physiol., Ill, 339-354, 1904; R. Tigerstedt, Nagel's Handb. d. Physiol., 1, 

 593-606, 1905; F. Kraus, Noorden's Handb. d. Pathol. d. Stoffw., 2 Ed., 1, 

 639-655, 1906; L. Krehl, Pathol. Physiologic, 5th Ed., 472-489, 502-566, 1907; 

 O. Cohnheim, Physiol. d. Verdauung und Ernahrung, 408-412, 1908-; Graham 

 Lusk, Ernahrung und Stoffwechsel, 2nd Ed., 71-80, 1910; P. F. Richter, Handb. 

 d. Biochem., 4", 137-140, 1910; E. Cavazzani, Arch, di Fisol., 8, 313, 523; 

 cited in Jahresber. f. Tierchem., 40, 520, 1910. 



