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absorption takes place much more slowly, dilatation of the pupil being 

 produced only after the lapse of about twenty minutes. 



Atropia and Alcohol. If we substitute alcohol instead of chloro- 

 form as a solvent, we find that absorption is extremely slow. Instead 

 of obtaining dilatation of the pupils in two or three minutes, we find 

 that an immersion of twenty to thirty minutes in the alcoholic solu- 

 tion will only produce very slight effects. At the same time the 

 local irritation is much less than that caused by chloroform. Alcohol 

 of various strength, from proof spirit upwards, had the same result 

 as a solvent. 



Atropia in watery with the addition of sufficient acetic acid for 

 its solution. The absorption of atropia in this state is very slow, 

 thirty minutes' immersion frequently producing no dilatation of the 

 pupils. Dilatation is then promoted by removal of the limb from 

 the solution. 



Watery extract of Belladonna. When rubbed over the leg and 

 tail, this substance was not found, after the lapse of an hour, to pro- 

 duce any dilatation of the pupil. 



Tincture of belladonna, with half its quantity of chloroform, pro- 

 duced dilatation at the end of fifteen minutes. The part was found 

 on removal to be completely insensible, and considerably swollen 

 from oedema, which lasted for several days. 



Atropia with strong alcohol and ammonia produced dilatation of 

 the pupil after twenty-five minutes' immersion. In this case, the 

 ammonia was added for the purpose of ascertaining how far irritation 

 of the part was conducive to absorption. Slight vesication was the 

 consequence of the presence of ammonia. The acceleration of the 

 absorption was very slight, as the solution produced no dilatation 

 until after twenty-four minutes' immersion. 



Absorption of Morphia. The foot of a young rat at one- third of 

 its growth was immersed in a solution consisting of half a grain of 

 acetate of morphia in twenty drops of alcohol and one drachm of 

 chloroform. In five minutes the pupils gradually dilated to the 

 maximum ; the limb was then withdrawn ; foot hot, red, and rather 

 swollen. Irritation of the skin caused no cry, the animal merely 

 withdrawing the part. Somnolency existed, from which any noise 

 aroused it, but only for a moment. When placed on its back, the 

 animal remained in that position. Respiration accelerated. Vision 

 when roused very imperfect, as was shown by its falling off the table. 



