336 



this occurred. I may mention, in passing, that where I have had 

 occasion to give chloroform after the injection of an acid into the cir- 

 culation, I have found the animal most easily killed by a very small 

 dose, and artificial respiration not of its usual avail in restoring ani- 

 mation. 



A good-sized healthy dog which had not been fed the day of the 

 experiment : the urine withdrawn gave no indication of the presence 

 of sugar : 1 1 ounce of the Pharmacopoeia phosphoric acid diluted 

 with an equal quantity of water injected slowly into one of the 

 jugular veins. The injection was made so slowly that it occupied 

 half an hour in being effected. In one hour's time from the com- 

 pletion of the injection, the urine was highly charged with sugar, 

 giving a copious orange-red reduction with the copper solution. 



A large and strong terrier- dog, not fed since twenty-four hours pre- 

 vious to the experiment : 2 ounces and 2 drachms of phosphoric acid 

 diluted with an equal quantity of water, introduced slowly into one 

 of the jugular veins. This was as much as the animal would bear 

 without seriously endangering its life. The urine, twenty minutes 

 after the completion of the injection, was slightly charged with sugar, 

 and one hour arid three quarters afterwards pretty highly so. 



It is thus evident that when a sufficient quantity of acid is intro- 

 duced into the circulatory system, the operations of life are so altered 

 that sugar appears in the blood to such an extent as to occasion a 

 strongly marked saccharine state of the urine. From all that I have 

 seen, it appears to me reasonable to conclude that this result is due 

 to a perverted condition of the processes belonging to the liver. The 

 unnatural state of the blood occasioned by the presence of the acid 

 seems to induce the change of amyloid substance into sugar. It seems 

 to promote that change, the result of chemical action, which occurs 

 with such activity after death, and which must be held in abeyance 

 under natural circumstances during life, sugar being found in the 

 system to so scarcely an appreciable extent. 



When the quantity of acid used has been large, the blood nearly 

 loses its power of coagulating. In some of my experiments, also, I 

 have noticed that such a morbid state has been induced as to lead to 

 an escape of blood from the vessels during life. I have met with 

 ecchymosis of the liver and stomach, an accumulation of blood in the 

 stomach and intestine, and the presence of blood in the urine. 



