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was of no use, for it very soon induced vomiting and was rejected. 

 Half an ounce of the phosphoric acid injected through a tube passed 

 down the oesophagus I found rapidly to occasion repeated vo- 

 miting efforts, the stomach having been previously empty. Re- 

 sorting to the use of chloroform, I therefore introduced the acid into 

 the duodenum, or some other portion of the small intestine. 



I have the record before me of the five experiments of this kind 

 that I have performed. They in the most striking manner show 

 that an excess of acid in the system occasions the production of sac- 

 charine urine. The following are the leading points belonging to 

 these experiments. 



No. 1 . In a medium-sized dog, which had not been fed for twenty- 

 four hours, 2 ounces of phosphoric acid were injected into the upper 

 part of the small intestine in g-ounce portions at intervals of half an 

 hour. Half an hour after the last half ounce had been injected, the 

 life of the animal was destroyed. The bladder was found distended 

 with urine, which gave a strong reaction of sugar. It had been ascer- 

 tained that it was previously free from this principle. The liver pre- 

 sented an ordinary appearance and behavour. There was no plugging 

 up of the portal vessels ; indeed the blood, which was collected during 

 the post-mortem examination, scarcely possessed any coagulating pro- 

 perty. 



No. 2. Fourteen drachms of phosphoric acid were introduced into 

 the duodenum of a largish dog which had not been fed since the day 

 previous. In an hour and a half's time there was a large quantity 

 of urine in the bladder, and it presented a strong reaction of sugar. 



No. 3. A medium-sized dog three hours after food : 10 drachms 

 of phosphoric acid injected into the duodenum ; urine in two hours' 

 time gave an orange-yellow reduction with the copper solution. Ten 

 drachms more were now again injected, and two hours afterwards the 

 life of the animal was destroyed. The urine gave a still stronger 

 reaction of sugar, namely, an orange-red reduction with the copper 

 solution. The liver presented a natural appearance. The blood 

 collected from the heart had undergone no coagulation whatever by 

 the following day. 



No. 4. A small dog five hours after food : 4 drachms of phosphoric 

 acid injected into the duodenum. In one hour and a half the animal 

 was killed. The urine did not contain any sugar. The liver looked 



