BY MEANS OF CATALYSTS. CREIGHTOX. 27 



The undecomposed bromcamphor-carboxylic acid was pre- 

 cipitated from the potassium hydroxide solution with dilute 

 hydrochloric acid, and -then purified by recrystallising from 

 ether. 1.485 grams of the acid were obtained. This amount, 

 dissolved to 16 ccm. in absolute alcohol, gave a rotation of: 

 a == 1.29, corresponding to [ajjf = + 6. 9 2 when measured 

 in a 2 dcm. tube. The specific rotation of the pure active acid 

 in absolute alcohol is + 77. 8, so therefore this preparation 

 contains 9$ active acid, whereas -*t should contain 27$ active 

 acid. This difference is probably due to loss during the 

 crystallisation, or possibly to racemizatioii. It would have 

 been better to have polarised the potassium hydroxide solution 

 of the acid. 



2. With quiniSine. In this case the undecomposed acid 

 should rotate to the left and the bromcamphor, formed by the 

 reaction, to the right. The most favourable point for stopping 

 the reaction is found from the curve (fi>. 3) to be at the end of 

 75 minutes, at which moment 80.9$ of the d- acid and 60.2$ 

 of the 1- acid has decomposed. As before two parallel 

 experiments with 5.0000 grams of inactive acid and 0.1000 

 gram of quinidine, dissolved in 55 ccm. of acetophenone, were 

 carried out at 40. The method and procedure were the same 

 as in the foregoing experiments. 



52 ccm. of the acetophenone solution of bromcamphor were 

 obtained, and 16 ccm. of this solution when polarised in a 2 

 dcm. tube gave a rotation of + 0.99, corresponding therefore 

 to 0.196 g. of active bromcamphor in the initial 55 ccm. 

 Calculations from the kinetic data show that 0.44 g. should 

 have been formed. In case of no other experimental error, this 

 difference between the experimental and theoretical quantities 

 of bromcamphor may be regarded as caused by racemization. 



The undecomposed bromcamphor-carboxylic acid was 

 removed from the potassium hydroxide solution with dilute 

 hydrochloric acid, and then purified. The acid obtained 

 weighed 1.535 grams. This was dissolved to 16 ccm. in 



