214 Messrs. Simonds and Cobbold on the Production [May 4, 



II. " On the Production of the so-called 'Acute Cestode Tuberculosis' 

 by the administration of the Proglottides of Tania mediocanel- 

 lata." By JAMES BEART SIMONDS, Esq., Professor of Cattle- 

 Pathology in the Royal Veterinary College, and T. SPENCER 

 COBBOLD, M.D., F.R.S., F.L.S. Received April 13, 1865. 



Neither of us having exhausted certain funds placed at our disposal for 

 scientific purposes (in the one case by the Royal Agricultural Society 

 through the Governors of the Royal Veterinary College, and in the other 

 by the British Association for the Advancement of Science), we have united 

 the resources which severally remained to us, and have instituted a series 

 of experiments in helminthology. These experiments, we are happy to 

 state, have proved, for the most part, eminently successful; moreover, 

 several of them not having been previously performed in this country, we 

 have ventured to think that at least the firstfruits of our combined research 

 in this particular relation might not unfitly be submitted to the notice of 

 the Royal Society. 



The subject selected for the experiment which we now, proceed to relate, 

 was a fine healthy female calf about a month old, living at the time on the 

 milk of its dam. As we were unable to obtain possession of the dam, 

 another cow was procured as a foster-mother, and the calf was placed with 

 her in order that it might receive a proper supply of milk in the natural 

 way. This plan was preferred to that of obtaining a weaned calf, as being 

 better calculated to preserve the health and strength of the young animal. 

 In the course of a few days the two animals became perfectly accustomed 

 to each other, the calf taking nourishment as often as was requisite. 



On the 21st of December, 18G4, we administered to the calf eighty mature 

 proglottides of the Teenia mediocanellata, mingled with a little warm milk 

 in the form of a draught. The potion was taken readily, and the worm- 

 joints probably entered the stomach in a perfect and unbroken condition. 

 No alteration was made in the subsequent management of the animals, but 

 a careful daily watch was kept upon the calf. 



' For some time no indications were perceived of disturbed health ; but on 

 the 6th of January, 1865 (the sixteenth day after the experiment), a careful 

 observation showed that the animal, although lively (and taking its milk and 

 likewise some hay with undiminished appetite), was nevertheless suffering 

 from some persistent cause of irritation. It would often be nibbling at its 

 legs and other parts of its body, and trying with its mouth and tongue to 

 get at places which were beyond its ordinary reach. It would also fre- 

 quently rub itself against the manger and sides of the loose box in which 

 it was confined. Desisting from this, it would arch its spine and stretch 

 out its hind limbs in an altogether unusual manner. It would also strain 

 itself repeatedly, at such times voiding either urine or faeces, or occasion- 

 ally both in small quantity. There was, however, no expression of suffer- 



