220 Dr. Bence Jones on the Rate of Passage of [May 4, 



had the head perfect, both his and Dr. Anderson's examples being quite 

 fresh. Mr. Brookhouse informed us that his specimen had been placed in 

 " very weak spirit" ; but it is clear that the worm had been injuriously 

 affected thereby, and the ova had lost their vitality. 



III. " On the Rate of Passage of Crystalloids into and out of the 

 Vascular and Non-Vascular Textures of the Body." By HENRY 

 BENCE JONES, A.M., M.D., F.R.S. Received April 26, 1865. 



(Abstract.) 



The paper is divided into five sections 



1st. On the method of analysis, and its delicacy. 



2nd. Experiments on animals to which salts of lithium were given, upon 

 the rate of their passage into the textures. 



3rd. On the rate of the passage of lithium-salts out of the textures. 



4th. Experiments on healthy persons, and on cases of cataract. 



5th. On the presence of lithium in solid and liquid food. 



1 . Three methods of analysis were followed, according as much or little 

 lithium was present : first, simply touching the substance with a red-hot 

 platinum-wire ; secondly, extracting the substance with water ; thirdly, 

 incinerating the substance and treating it with sulphuric acid, and ex- 

 hausting with absolute alcohol. ^ * of a grain of chloride of lithium 



in distilled water could be detected, and * nnn to nn * of chloride 



.,,. , . . 6,000.000 2,000,000 



of lithium in urine. 



2. On Rate of Passage into the Textures through the Stomach. 

 Even in a quarter of an hour three grains of chloride of lithium, given 

 on an empty stomach, may diffuse into all the vascular textures, and into the 

 cartilage of the hip-joint and the aqueous humour of the eye. In very young 

 and very small guinea-pigs which have received the same quantity of lithium, 

 in thirty or thirty-two minutes it may be found even in the lens ; but in an 

 old pig in this time it will have got no further than the aqueous humour. 

 If the stomach be empty, in an hour the lithium may be very evident in the 

 outer part of the lens, and very faintly traceable in the inner part ; but if the 

 stomach be full of food, the lithium does not in an hour reach the lens. 

 Even in two hours and a half lithium may be more marked in the outer than 

 in the inner part of the lens. In four hours the lithium may be in every part 

 of the lens ; but less evidence of its presence will be obtained there than from 

 the aqueous humour. In eight hours, even, the centre of the lens may show 

 less than the outer part. In twenty-six hours the diffusion had taken place 

 equally throughout every part of the lens. If the lithium is injected under 

 the skin, in ten minutes it may be found in the crystalline lens, and even 

 in four minutes, after the injection of three grains of chloride, the lithium 

 may be in the bile, urine, and aqueous humour of the eye. 



