1865.] Crystalloids into and out of the Tissues. 221 



3. On the Rate of Passage out of the Textures. 



After two grains of chloride of lithium, in six hours the lithium was 

 more distinct in the outer than in the inner part of the lens. In twenty- 

 four hours no difference in the different parts of the lens was detectable. 

 In forty-eight hours no difference was observed. In ninety-six hours no 

 lithium was detectable in the lens or cartilage of the hip-joint. The urine 

 showed lithium very distinctly even in one drop. 



After one grain of chloride of lithium, in five hours and a half the lithium 

 was more distinct in the outer than in the inner part of the lens. In 

 twenty-four hours and a half there was no difference throughout the lens. 

 In forty-eight hours the watery extract of the lens showed faint traces of 

 lithium. In seventy-two hours and a half (three days) the alcoholic 

 extract of the lens showed no lithium. The urine still showed lithium 

 distinctly in one drop, and it continued to be found in the watery or 

 alcoholic extract for twenty-one days. 



After half a grain of chloride of lithium, in three hours and fifty minutes 

 traces of lithium could be found in the lens, and for thirty-seven or thirty- 

 eight days traces of lithium could be found in the urine. 



After a quarter of a grain of chloride of lithium, in five hours and a 

 quarter the aqueous humour showed lithium, and all the organs showed 

 lithium, but none was in the lens. In another pig, in twenty-four hours 

 all the organs showed less lithium, and none was found in the aqueous 

 humour. 



After a quarter of a grain, in five hours and thirty-five minutes lithium 

 was distinct in the aqueous humour, and very faintly traceable in the lens ; 

 and after sixteen days the minutest traces of lithium could be detected in 

 the lens, the liver, the kidney ; but no trace could be found in the blood. 



After three grains of chloride of lithium, in four hours lithium was in the 

 hair of the belly, and for thirty-two days the urine showed lithium very 

 distinctly. The thirty-third day after the lithium the lens was found to 

 contain minute traces of lithium, and even after thirty-nine days the 

 lithium was in the alcoholic extract of the urine. 



With three grains of chloride of lithium, a young pig in half an hour 

 had lithium in the watery extract of the lens. In the same time an old pig 

 had no lithium in the lens. 



With two grains, a young pig in six hours had lithium distinctly through- 

 out the whole lens. An old pig in the same time had lithium in the outer 

 part of the lens, but scarcely the minutest trace in the inner part of the 

 lens. 



4. Experiments on Healthy Persons and on Cases of Cataract. 

 Ten grains of carbonate of lithia, taken three or four hours after food by 

 a man, require from five to ten minutes to pass from the stomach to the 

 urine, and this quantity of lithia will continue to produce traces of lithium 

 in the urine for from six to seven days. 



s2 



