402 Dr. B. Jones on the Passage of Crystalloids [1865. 



2. Experiments on animals to which salts of lithium were given, upon the 



rate of the passage into the textures. 



Experiment 1 . Two guinea-pigs were fed for several days on the same 

 food. One was killed, and the urine, the nails, hair, blood, bones, muscles, 

 nerves, cornea, and crystalline lens were examined by the spectrum, and 

 no trace of lithium was found anywhere. The other was given half 

 a grain of chloride of lithium for seven days, and for two days one grain. 

 It was then killed, and the lithium was found everywhere, even in the 

 cornea, crystalline lens, hair, and toe-nails. In these it was more distinctly 

 present than anywhere else, so that it probably came from the urine. 



Experiment 2. Another guinea-pig, fed on the same food as the first 

 two, was given only half a grain of chloride of lithium for three days. 

 The third morning the lithium was detectable, by analysis, in the hair ; 

 the fourth day it was killed, and the lithium was found everywhere, as 

 in the last instance. 



Experiment 3. Another, after the hair and nails had been examined for 

 four days and no lithium found, was given three grains of chloride of 

 lithium. In two hours and a half lithium was detected in the hair of the 

 belly, though in six hours none was found in the hair of the back ; much 

 more was then in the hair of the belly. In twenty- six hours it was killed. 

 Lithium was found everywhere, both in the outer and inner part of the 

 lens very distinctly, and in the cartilage of hip- and knee-joints. The 

 spleen and liver seemed to have less lithium than the vitreous and aqueous 

 humour and the lens. 



Experiment 4. A guinea-pig was given three grains of chloride of 

 lithium, and in twenty-four hours it was killed. Lithium was found in the 

 cartilage of the hip- and knee-joints, in the centre of the lens, in the nails, 

 and in the outer moisture of the eye. 



Experiment 5. To another, the hair of which gave no trace of lithium, 

 were given three grains of chloride of lithium, and it was killed in eight 

 hours ; as usual, lithium was found in all the organs by far the most 

 in the kidneys. Little was found in the blood. It was quite evident 

 in the cartilage of the hip-joint, and very distinct in the outer layer of 

 the crystalline lens, but none at all could be found in the centre of the 

 lens. Both lenses were examined more than six different times with 

 the same result. 



Experiment 6. In a guinea-pig, much younger than the last, which 

 was killed eight hours after three grains of chloride of lithium, the 

 whole lens was penetrated, the smallest particle, even one-twentieth 

 the si/e of a pin's-head, taken from each part of the lens, showing the 

 lithium distinctly. The whole lens of another pig that had taken no 

 lithium was- burnt, and did not show the slightest trace of lithium. 



Experiment 7- Another guinea-pig was given three grains of chloride of 

 lithium, and it was killed in four hours. Lithium was found in the fibrin, 

 serum, and corpuscles of the blood, in the cartilage of the hip-joint, and in 



