404 Dr. B. Jones on the Passage of Crystalloids [1865. 



Experiment 14. An old guinea-pig, also fasting for about thirty-six 

 hours, was given the same quantity of chloride of lithium, and was also 

 killed in half an hour. No lithium could be detected before the dose in 

 the urine, nor in the toe-nail of one leg. After taking the lithium, the 

 animal was wrapped up in a cloth, the leg only being left out, to prevent 

 it from licking the toe ; after death, the nails of this leg showed that some 

 lithium was there. The sciatic nerve showed traces of lithium. The 

 cartilage of the hip-joint, when touched with red-hot wire, showed no 

 lithium, but scrapings from the surface showed traces of lithium. The 

 humours of the eye showed traces of lithium, but the lens showed no 

 lithium even in the watery extract. The brain showed only exceedingly 

 faint traces of lithium. The stomach was almost completely empty. 



Experiment 15. A guinea-pig was kept fasting for twenty-four hours ; it 

 was then given three grains of chloride of lithium, and it was killed in a 

 quarter of an hour. Lithium was found in the bile, liver, kidney, and 

 blood very distinctly ; very faintly in the brain and in the cartilage of 

 the hip-joirt, and in the humours of the eye. None was found in the lens. 

 The stomach contained only some water, no solid food. 



Experiment 16. Three fresh guinea-pigs were taken, one was killed 

 without taking any lithium. The urine showed no lithium in one drop, 

 but the ash of the urine showed traces of lithium. No lithium could 

 be detected in any of the organs, not even by treating the ash of the 

 kidney with sulphuric acid and alcohol. 



The two remaining animals were each given one quarter of a grain of 

 chloride of lithium. 



The first was killed in five and a quarter hours afterwards. All the 

 organs, except the lens of the eye, showed lithium by simply touching 

 them with the red-hot wire. The urine and the bile showed the lithium 

 very distinctly. The blood showed lithium faintly. The vitreous and 

 aqueous humours showed traces of lithium. An aqueous extract of the 

 lens showed no lithium. The animal was a large and old one, and the 

 stomach was nearly empty. 



The second was killed twenty-four hours after one quarter of a grain. 



None of the organs showed any lithium by simply touching them with 

 a red-hot wire. The ash of the kidney showed traces of lithium, and so 

 did the ash of part of the liver. No lithium could be detected either in 

 the vitreous and aqueous humour or in the lens ; the urine and the bile 

 showed lithium in one drop, but only faintly. Possibly the lithium had 

 not been absorbed in this case. The state of the stomach, as regards 

 food, was not recorded. 



" It follows from these experiments, that when no lithium is taken no 

 lithium can be found in the different textures, but that even in a quarter 

 of an hour three grains of chloride of lithium given on an empty stomach 

 may diffuse into the cartilage of the hip-joint and into the aqueous 

 humour of the eye. In very young and very small guinea-pigs the same 



