410 Dr. B, Jones on the Passage of Ci-ystalloids [1865. 



After one grain of chloride of lithium, in five hours and a half the lithium 

 was more distinct in the outer than in the inner part of the lens. In twenty- 

 four hours and a half there was no difference throughout the lens. In 

 forty-eight hours the watery extract of the lens showed faint traces of 

 lithium. In seventy-two hours and a half (three days) the alcoholic ex- 

 tract of the lens showed no lithium. The urine still showed lithium dis- 

 tinctly in one drop, and continued to do so for seventeen days in the 

 alcoholic extract. 



After a quarter of a grain, in five hours and thirty-five minutes lithium 

 was distinct in the vitreous and aqueous humours, and very faintly in the 

 lens. After sixteen days, the minutest traces of lithium were detected in 

 the lens, the liver, and the kidneys, but no trace could be found in the 

 blood. (This animal had perhaps somehow eaten the minutest quantity of 

 lithia in the food*.) 



After half a grain of chloride of lithium, in three hours and fifty minutes 

 traces of lithium could be found in the lens, and for thirty-seven or thirty- 

 eight days traces of lithium could be found in the urine. 



After three grains of chloride of lithium, in four hours^ lithium was in 

 the hair of the belly, and for thirty-two days the urine showed lithium very 

 distinctly. The thirty-third day after the lithium the lens was found to 

 contain minute traces of lithium, and after thirty-nine days the lithium was 

 in the alcoholic extract of the urine. 



4. Experiments on the Bate of Passage of Lithium through the Human 

 Body, and into and out of the Crystalline Lens. 



Experiment 1 . A man took ten grains of carbonate of lithia dissolved in 

 water, four hours after his midday food. 



In five minutes no lithium could be detected in the urine. 



In ten minutes lithium was evident. 



In eighteen hours it was present in the nails of the hands and feet, and 

 in the hair of the beard and body ; apparently most where there was most 

 perspiration. No lithium could be found in the hair of the head or 

 whiskers. 



In forty-two hours very perceptible. 



In sixty-six hours another dose of ten grains was taken. 



In ninety hours lithium was detectable in the hair of the head. 



For three days after the second dose it was perceptible in one drop of the 

 urine, but rather doubtful in the hair and in the nails. 



For six days after the second dose lithium was detectable in the urine. 



For eight days after, no lithium could be detected when the eighth of an 

 ounce of urine was evaporated. 



* The skin of guinea-pigs throws off lithium, and it collects on the hair and nails, so 

 that it is possible for the animal to redose itself with lithium from its own body, and thus 

 to keep lithium passing in and out of the textures much longer than if a single dose only 

 were taken. 



