106 Messrs. T. L. Brunton and J. Fayrer on the [Jan. 22, 



2 AS. Heart is still acting feebly and slowly ; brachial nerves exposed 

 and irritated. 



At 46'5 centims. contractions in both arms. 



2.49. The heart has now ceased to beat, except a faint pulsation in the 

 auricles. 



Muscles of arms and legs exposed and irritated by single induced shocks. 

 6-5 centims., muscles of both arms contract ; muscles of both legs con- 

 tract, but somewhat more strongly. 



In this experiment there is no evidence of paralysis either of the nerves 

 or muscles ; death appears due to paralysis of the spinal cord. This is 

 caused by the action of the poison ; for the circulation still continued, 

 though feebly, after all reflex action had ceased. 



Experiment XL VIII. 



A ligature was passed under the right sciatic nerve of a frog and tightly 

 tied round the limb, so as to constrict the whole of the thigh, with the 

 exception of the nerve, and completely arrest the circulation. 



At 1.8 half a drop of cobra-poison (1st supply), diluted with J cub. 

 centim. of water, was injected into the dorsal lymph-sac. 



1.12. The animal is sluggish. 



1.15. Crawls about but sluggishly, and keeps the unligatured limb 

 drawn up close to the body. 



1.20. The frog is more sluggish. 



1.23. The hind limbs seem paralyzed; the fore limbs still move, but 

 much less than before. 



1.30. Frog almost motionless. Contractions of the fore llimbs still 

 occur ; but they no longer respond when pinched. 



1.57. There is a faint motion in the limbs. 



2.18. Frog is dead. Much ecchymosed. 



On irritating the lumbar nerves in the abdominal cavity by an induced 

 current, the poisoned leg contracted rather more than the non-poisoned leg. 



On irritating the sciatic nerves in the thigh, below the level of the liga- 

 ture, the contractions of the poisoned leg were much less vigorous than 

 those o the non-poisoned leg. 



Electrodes were then placed in the spinal cord, and the cord irritated 

 by an induced current. 



2.34. When irritation is applied in this way the fore limbs contract, but 

 not the hind limbs. 



When the cord is irritated lower down, the non-poisoned leg responds 

 to the irritation, but the poisoned leg does not. 



The muscles of the ligatured leg respond to the direct application of 

 electricity more freely than the other muscles. 



In this experiment the poison employed had not been coagulated or 

 dried, and the dose was somewhat small. The failure of reflex action 

 while voluntary motions still continued in the nerves, shows that the cord 



