312 Presents. [Jan. 31, 



right leg extremely oedematous. Large haemorrhages over upper part 

 of leg and lower part of abdomen. 



Dog II. 17 Ibs. 12 c.c. of solution injected, but ten times diluted, 

 and injection lasting five minutes. Femoral vein tied close to liga- 

 ment. Dog killed next day. No trace whatever of clotting anywhere. 

 Leg absolutely free from the slightest trace of oedema or haemorrhage. 



So far as my observations go, the tendency to oedema is the first 

 symptom of fibrinogen intoxication, i.e., it is more easily produced 

 than any other. 



One of the most important features in these observations lies in 

 their relationship to many important diseases. I have pointed out 

 the conditions which must prevail to produce a fibrinogen intoxica- 

 tion. It is improbable that diseased conditions are often set up by a 

 sudden large flow of lymph into the blood ; but it is certain that the 

 other conditions, the slowing of the circulation in the neighbourhood 

 of the thoracic duct, is a common incident, particularly I may mention 

 valvular disease of the heart and obstruction to the circulation 

 through the lungs, as conditions which necessarily produce this result. 

 It is a dogma of medicine that cardiac dropsy as a symptom of cardiac 

 failure, is due to the mechanical obstruction of the circulation. My 

 observations lead me to the conclusion that the danger in cardiac 

 disease is fibrinogen intoxication ; and that the symptoms of cardiac 

 disease e.g., dropsy, formation of intravascular clots, haemorrhagic 

 infarction, fever, &c. are largely dependent on this condition. 



Presents, January 31, 1889. 

 Transactions. 



Amsterdam : Koninldijke Akademie van Wetenschappen. Ver- 

 handelingen (Letterkunde). Deel XVII. 4to. Amsterdam 

 1888; Verhandelingen (Natuurkunde). Deel XXVI. 4to. Am- 

 sterdam 1888. The Academy. 

 Koninklijk Zoologisch Grenootschap ' Natura Artis Magistra.' 

 Bijdragentot de Dierkunde. Aflevering 14-16. 4to. Amsterdam 

 1887-88 ; Feest-Nummer uitgegeven bij Gelegenheid van het 

 50-jarig Bestaan van het Genootschap. 4to. Amsterdam 1888. 



The Society. 



Brussels : Academic Royale des Sciences. Annuaire. 1889. 12mo. 

 Bruxelles. The Academy. 



Buitenzorg : Jardin Botanique. Annales. Vols. II, III, IV, V, 

 VI. Parts (respectively) 2, 1, 1-2, 1, 2. 8vo. Leide 1885-87. 



Dr. Treub. 



Calcutta: Asiatic Society of Bengal. Journal. 1888. Nos. 1-2. 

 8vo. Calcutta ; Proceedings. 1888. Nos. 2-8. 8vo. Calcutta. 



The Society. 



