22 THE CELL DOCTRINE. 



ner* (1830), F. Arnoldf (1836), Dutrochetj; (1837), 

 Kaspail (1839); all except Hodgkin admitting in 

 greater or less degree the importance of the globule 

 as an ultimate physical element ; while it is evident, 

 also, that there was much confusion in the use of 

 terms, the words globule, granule, and molecule, \\ 

 being often indiscriminately used, and the word 

 globule sometimes used to indicate what is now clearly 

 recognized as the "cell." 



Prochaska,Tf in 1779, described the brain as made 

 up of globules eight times smaller than blood glob- 



* Baumgartner, K. H., Lehrbuch der Physiologic mit Nutz- 

 anwendung auf die arztliche Praxis. 1853. 



f Arnold, F., Lehrbuch der Physiologie des Menschen. Erst. 

 Theil, Zurich: 1836. 



J Dutrochet, Me"moires pour servir a 1'Histoire Anatomique et 

 Physiologique des Vegetaux et des Animaux. T. i, ii, Atlas. 

 Paris: 1837. 



$ Raspail, Systeme de Chimie Organique. 2e ed., T. i, ii. 

 Brus. : 1839. Avec Atlas. 



|| The German authors of this period and even more recent 

 times (Henle, 1841, Virchow, 1858), at least in speaking of the 

 development of histology, seem to use indiscriminately the terms 

 granule or molecule, and globule, whereas they are morphologically 

 something distinct. A globule is usually held to be a body, 

 which, under the microscope, is more or less spherical inform, 

 possessing a bright centre, and dark outline, the width of this 

 outline being directly as the difference between the refracting 

 power of the globule itself and that of the menstruum in which it 

 floats. Thus, the dark outline of a globule of oil floating in water 

 is wider than that of the same globule floating in glycerine. A 

 granule or molecule, on the other hand, is indeterminate in size and 

 shape, and appears as a mere dot under the highest powers of the 

 microscope. It is true that what appears as a granule under a low 

 power, may appear as a globule under a higher. 



fl Prochaska, Opera Minora, Part I, p. 342. 



