42 THE CELL DOCTRINE. 



MARTIN BARRY, 1840. 



It was in his first series of embryological researches, 

 published in Part II, of the " Philosophical Transac- 

 tions " of London, for 1838, p. 310, that Dr. Martin 

 Barry declared "that the germinal vesicle (which he 

 regarded as the nucleus), and its contents constitute 

 throughout the animal kingdom the most primitive 

 portion of the ovum." In his second series, Part 

 II, 1839, in stating that the germinal vesicle returns 

 to the centre of the cell, post coitum, he first pointed 

 out that the nucleus does not always accompany the 

 cell through the whole vital process at the periphery 

 (the original position according to Schleiden and 

 Schwann), but that it also passes to the centre, as 

 we now well know. Here, also, he declares, but in 

 his third series, Part II, 1840, he demonstrates that 

 there arise in the parent vesicle, two or more infant 

 vesicles, the parent vesicle disappearing by liquefac- 



of true nucleated cells." 1 Kolliker, 2 one of the foremost exponents 

 of the cell doctrine of the present day, in 1844 expressed his dissent 

 from the idea of unity in the mode of cell formation, and states that 

 if there is a single method of cell formation which is invariable, 

 it remains to be discovered. Mr. Taget, 3 so well known from his 

 Lectures on Surgical Pathology, suggested in 184G, that a cell 

 might arise in some other way than from a nucleus, since he had 

 met morbid growths composed entirely of fibres, in which not a 

 nucleated cell was present. Most of which statements are, how- 

 ever, reconciled by the information which has since been added to 

 our knowledge of the subject. 



1 Henle, Traite d'Anatomie Generale. Trad. d'Alleinand, par A. J. 

 Jourdain, 2 vol. Paris : 1843, torn. 1, p. 374. 



2 Kblliker, Entwickelungsgesehichte der Cephalapoden. Zurich: 1844. 



3 Paget, Report on the Progress of Anatomy and Physiology. Br. and 

 For. Med. Rev., July, 1846. 



