THE CELL DOCTRINE. 89 



Virchow a local one, the result of a proliferation of 

 the connective tissue corpuscle of the part, and 

 having no dependence upon the blood, is regarded 

 by Beale as the result of a proliferation of minute 

 particles of germinal matter (very much smaller than 

 white blood corpuscles), which have passed out 

 through the capillary walls with the liquor sanguinis. 

 In all inflammatory processes and fevers, this is 

 believed by Dr. Beale to take place to a greater or 

 less extent, the little masses of germinal matter or 

 nuclei in the capillary walls also taking part, often 

 increasing in size to such degree that they materially 

 obstruct the passage of the blood, and by dropping 

 off portions give rise to bodies floating in the blood 

 precisely similar to white blood corpuscles, or pus 

 corpuscles; indeed, Dr. Beale considers that this may 

 be one of the sources of origin of the white blood cor- 

 puscle.* 



So, also, tubercle is believed by Dr. Beale to result 

 either from the multiplication of masses of germinal 

 matter which have passed through the capillary walls 

 from the blood, or from the masses of germinal matter 

 usually termed nuclei, in connection with the capillary 

 walls. He says, in illustration, "In a case of tubercle, 

 which was very rapidly developed upon the surface 

 of the pia mater, in a man of tubercular constitu- 

 tion, I proved most distinctly, that the tubercles were 

 connected with the vascular walls, and that if the 

 nuclei had not given origin to them, they were cer- 



* Beale, Microscope in Clinical Medicine, 3d ed. London : 

 1867, p. 166. 



