Experimental Tnvextigation into the Pathology of Cancer. 397 



We are much indebted to Mr. Horsloy, Professor Superintendent 

 of the Brown Institution, for his kindness in allowing us every 

 facility at the Brown Institution for carrying on our work, and for 

 his ever ready help in many ways and on many occasions. 



Short Abstract of tlie most important of our Transplantation Experiments. 



In all the experiments recorded the tumours were removed from 

 the human subject, except in the case of two of the experiments on 



dogs. 



Monkey (1). Into the abdominal cavity were placed three small 

 pieces of scirrhous carcinoma of breast that had been previously 

 incubated for seven days at 37 C. 



Lived 37 days death from diarrhoea. 



After death, the shrunken remains of the grafts were found 

 adherent to the peritoneum. 



Monkey (2). A piece of a scirrhous carcinoma of breast placed in 

 the abdominal cavity ; another stitched with catgut into the biceps. 



Lived 115 days. Was killed on account of the appearance of a 

 large, lobulated, pinkish swelling at the site of the abdominal wound. 



After death, this mass was found by microscopic examination to be 

 a granuloma, in the base of which was a small piece of prolapsed 

 omentum. 



No trace of tumour grafts within the abdomen or in the biceps. 



Monkey (3). Transplantation into both biceps muscles and into 

 muscles of outer part of right thigh. 



Death from septicaemia on the 6th day. 



The tumour was slightly ulcerated. The gelatine tubes showed a 

 rapid and abundant growth. 



Monkey (4). Into the left biceps was stitched a piece of scirrhous 

 carcinoma of the mamma, and another piece into the right thigh. 

 Lived 66 days. Wounds not quite healed. No remains of grafts 

 found. Death from cold. 



Monkey (5). A piece of scirrhous carcinoma stitched into left 

 biceps, and a second placed beneath the skin of the back. 



Lived 15 days. Death from cold. Wounds healed. 



Grafts encapsuled by connective-tissue, lemon-yellow in colour. 



Microscopic sections of the tumour in both situations show it to 

 be the seat of coagulation necrosis. Around the portion in the 

 biceps is a zone of granulation tissue, which is invading the substance 

 of the tumour, the two being intimately mingled at the periphery of 

 the latter. There are no leucocytes or other living cells in the 

 central portion of 'the graft. Similar appearances obtain in the 

 microscopic sections of the piece of tumour embedded in the sub- 

 cutaneous tissue of the back. 



