Experimental Investigation into the Pathology of Cancer. 399 



was killed. Post mortem. No peritoneal adhesions. No sign of the 

 graft. All the viscera healthy. 



Dog (2). Abdominal section and insertion of a piece of scirrhus 

 1^ inch in diameter, and inch in thickness. Nine days later the 

 animal was killed with chloroform. Post mortem. Circumscribed 

 abscess around the shreddy remains of the graft adherent to liver 

 and stomach. No peritonitis. 



Dog (3). 1st Experiment. Into the abdominal cavity was placed 

 a scirrhus of the breast, If inch in diameter and discoidal. 



2nd Experiment. 390 days after the 1st experiment, a whole 

 scirrhus of the breast with some of the surrounding fat was placed 

 in the subperitoneal tissue. 



'3rd Experiment. 170 days after the 2nd experiment, into the 

 peritoneal cavity was placed a slice of a subperitoneal round-celled 

 chondrifying sarcoma of humerus, 1 X 1^ X inch in volume. This 

 was pushed to the right of the middle line, a similar slice being 

 pushed to the left. The slices were cut in the spray, all surfaces 

 previously exposed being rejected. One of the slices included the 

 growing margin of the growth. Is still alive and well, 650 days 

 after the 1st experiment.* 



Dog (4). 1st Experiment. Beneath the skin of the right side of 

 the thorax, by means of a valvular incision, was placed a small 

 scirrhus of the breast, about as large as a horse bean, most of the 

 fat, having been previously cut away in the spray. Primary union of 

 wound. 



2nd Experiment. 240 days after 1st experiment, into the 

 abdominal cavity was placed the greater part of a breast with two 

 scirrhus masses in it. Death six days later from haemorrhage into 

 the abdominal cavity. Post mortem. No trace of the first graft 

 beneath the skin of the thorax. No tumours in internal organs. 



Dog (5). 1st Experiment. Beneath the skin of the back was 

 placed, an hour after its removal from the patient, a square slice 

 (| inch along its sides) of a spindle-celled sarcoma taken from 

 amongst the muscles of the thigh. 



Wound healed by first intention. 



2nd Experiment. Beneath the skin of the back, 400 days after the 

 1st experiment, was placed a wedge-shaped piece, about three- 

 quarters of an inch in depth, of sarcoma, including the periphery. 

 This was removed from a tumour filling the zygomatic fossa of 

 another dog, which was kept under ether while the graft was taken, 

 the animal being subsequently killed. Warm saline solution was 

 poured over the piece before its insertion beneath the skin. The 



* July 8th. Animal killed 760 days after 1st experiment. Post mortem. No 

 sign of tbe grafts. Viscera healthy. 



