400 Messrs. C. A. Ballance and S. G. Shattock. 



post-mortem on the dog from which the graft was taken showed no 

 growths in any of the internal organs. 



The wound healed by first intention and 50 days later no trace of 

 the tumour could be felt. The tumour on microscopical examination 

 was seen to be a small ronnd-celled sarcoma containing many giant 

 cells and undergoing calcification in places.* 



Dog (6). 1st Experiment. Beneath the skin of the side of the chest 

 was placed a piece of scirrhus of the breast 1 inch in diameter and 

 ^ inch in thickness. The tumour was discharged by suppuration 

 and the wound healed. 



2nd Experiment. 112 days after the 1st experiment, an entire 

 scirrhus of the breast was placed in the abdominal cavity, the tumour 

 being sliced into three pieces, which were forced into different situa- 

 tions. 



320 days after the 2nd experiment the animal was in good 

 health. On this day it was killed. Post mortem. Omentum ad- 

 herent to linear cicatrix in abdominal wall. No sign of the graft dis- 

 cernible. No disease of any of the viscera. 



Dog (7). Into the abominal cavity was placed a square slice 

 |- inch along its sides, and ^ inch thick, cut from a tumour which 

 had been a very short while previously excised from the ischiorectal 

 fossa of another dog. A second piece of the same tumour was 

 placed beneath the skin on the right side of the front of the 

 thorax. 



Wounds healed by first intention. Animal in good health 270 days 

 afterwards. The tumour on microscopical examination proved to be 

 a squamous-celled carcinoma with cysts.f 



Sheep (1). Beneath the skin of the back under strict anti- 

 septic precautions was placed a square slice from a subperiosteal 

 round-celled sarcoma of the humerus, 2 inches square, and ^ inch 

 in thickness : this was pushed for some inches into the subcu- 

 taneous tissue beyond the incision. The piece included at one of 

 its borders the growing margin with the healthy tissues imme- 

 diately connected with it. Three weeks after the operation there 

 was a fluctuating swelling at the site of the graft, and six weeks 

 after the operation the graft was discharged in the state of necrosis). 

 On the 108th day the animal, apparently in good health, was killed. 



Post mortem. Sheep healthy in every respect. 



Sheep (2). Beneath the skin of the back was placed a slice 

 of scirrhus of the breast with a rim of the surrounding fat, the 

 whole being If inch in diameter and about ^ inch in thickness. 



* July 8th. Animal killed 590 days after the 1st experiment. Post mortem. 

 No trace of the grafts. No sign of cancerous infection. 



t July 8th. Animal killed 400 days after the experiment. Post mortem. No 

 sign of graft. Viscera healthy. 



