402 Experimental Investigation into the Pathology of Cancer. 



variance. Senger* and Sennf have never observed tumour formation 

 to ensue after grafting. This accords with the results of earlier 

 observers in this field, Sir William Savory and Sir John Simon. In 

 none of these experiments were the animals suffered to live any con- 

 siderable time, and it is in this that they are not satisfactory. Of 

 carcinoma it is especially true that it is a disease of advancing years. 



In experiments made from animal to animal Doutrelepont obtained 

 only negative results, as also did Senn. 



We have already noticed Hanau's successful inoculations of squa- 

 mous-celled carcinoma of a rat into the abdominal cavities of two 

 other rats ; and it remains to mention the transplantation experi- 

 ments of Dr. Wehr,| who successfully transferred a vaginal carci- 

 noma of a dog into the subcutaneous tissue of the belly of another 

 female dog. Valvular apertures in the skin were made in four 

 places and a piece of tumour was pushed into each with antiseptic 

 precautions. The experiment was performed in December, 1887. 

 The nodules increased in size and the animal died in June, 1888, 

 much emaciated. At the autopsy the retroperitoneal glands and the 

 spleen were occupied by secondary growths. 



By injecting cancer juice triturated and mixed with distilled water 

 into the jugular vein of dogs, certain results have followed in the hands 

 of Langenbeck, Follin, and Lebert. Nodules have been fonnd in some 

 of the internal organs, but the results are of no value owing to the 

 lack of sufficient histological investigation as to their nature. For it 

 is well-known that inert solid particles if lodging in internal organs 

 excite a local inflammation and production of fibroid tissue, which 

 may attain some size ; this is a well-known occurrence in the lung in 

 masons, for instance. 



Hahn (' Berlin Klin. Woch.,' 1888) has shown that in the human 

 subject it is possible to transplant a cancerous nodule from one spot 

 to another in the same person, with the result of the graft increasing 

 in size and invading the surrounding tissues. 



In the ' Progres Medical,' No. 16 (1889), Darier reports that he 

 has found coccidia in the epithelium in " Paget's Disease of the 

 Nipple." He concludes that not only this disease, but the carcinoma 

 that often follows it, are caused by the parasite ; and at a meeting of 

 the Pathological Society (March, 1890), J. Hutchinson, jnnr., 

 showed specimens which he believed were confirmatory of Darier's 

 observation. 



* " Studien zur Aetiologie des Carcinoma " ('Berlin Klin. Wochenschrif t,' 1888). 



f " Surgical Eelations cf Micro-organisms " (' Transactions of the American 

 Surgical Association,' vol. 6, 1888). 



$ ' Transactions of the eighteenth Congress of German Surgeons,' Berlin, 1889, 

 " Weitere Mittheilungen iiber die positiyen Ergebnisse der Carcinomuberimpfungen 

 ron Hund auf Hund." 



Neisser, in the ' Viertelj. f. Derm. u. Syphilis,' 1888, expresses his belief that 



