268 Messrs. A. A. Kanthack and W. B. Hardy. [Nov. 17, 



f" (a) Eosinopliile cells ; nucleus 

 horse-shoe shaped or lobed ; 

 do not ingest particles ; are 

 motile unicellular glands. 



Normal. < 



I. Cells normally free in the 

 blood and in the lymph. 



L 



II. Cells very few in number 

 and small in normal 

 lymph. Normally pre- { 

 sent in the lacunar 

 spaces of areolar tissue. 



(b) Hyaline cells, free from specific 



granulation ; nucleus round 

 with central nucleolus. Pha- 

 gooytic, i.e., they possess the 

 power of ingesting and digest- 

 ing discrete particles. 



(c) Basophile cells, spherical, with 



scanty protoplasm when 

 small ; angular, rounded or 

 flattened when large ; cell 

 substance charged with tiny 

 basophile granules, which give 

 a vivid rose colour with methy- 

 lene-blue. Large oval or 

 round vesicular nucleus, some- 

 times containing irregular 

 chromatin mass and filaments. 



Abnormal. 



III. Large amoeboid cells ; ~) 



vacuolate, frequently j Giant cells formed by fusion of 



with ingesta in the ! hyaline cells, similar to the 



vacuoles, multinuclear, j large phagocytic cell of Asia- 



very active and phago- j cus. 

 cytic. J 



f Nucleated cells budded off from 



IV. Small bodies, eitherround | tlie eosinophile or hyaline 



and quiescent or amoe- { 



Non-nucleated bodies produced by 

 l^ breaking up of red corpuscles. 



The hyaline cell is less resistant than the eosinophile cell. Eough 

 manipulation causes a rapid bursting up of the cell, thus recalling 

 the hyaline explosive corpuscles of Astacus. 



We have studied the functions of these cells in relation to their 

 anti-bacillary action (1) by taking samples of lymph from a Frog at 

 varying intervals after the injection of bacilli, &c. ; (2) by inocu- 

 lating hanging drops suspended in moist chambers and kept at 

 different temperatures, the chambers being sufficiently large to afford 

 plenty of oxygen. By the second method we have been able to 

 observe the conflict between cells and bacilli for continuous periods 

 of eight to nine hours. The same cells and bacilli have been watched 

 for the whole period. 



In the same manner we have also examined the effect of the injec- 

 tion of finely-divided coagulated proteid (boiled white of egg solu- 

 tion), Indian ink, vermilion, egg albumen, and anthrax spores. At 

 first we used curarised Frogs to obtain lymph, and this led to the 

 discovery that curare produces a profound alteration in the wandering 

 cells. 



