270 Messrs. A. A. Kanthack and W. B. Hardy. [Nov. 17, 



fined to the more mobile peripheral cell substance. Whether the 

 eosinophile cells or the bacilli win the fight depends largely on their 

 relative numbers. The bacillus is only injured near the eosinophile 

 cell ; there the contents become rapidly cuixlled and irregular in 

 appearance, and may be completely dissolved (it should be noted 

 that Leber has shown that pus dissolves copper, and even platinum, 

 and Kanthack has .shown itbat the pus cell is the eosinophile cell). 

 If the bacillary chains are in great number, , then there may not be 

 eosinophile cells enough to attack them all, although the eosinophile 

 cell will extend itself to most attenuated lengths in order to be able 

 to attack as great a length of chain as possible. Even where the 

 chain is not directly attacked, the near presence of eosinophile cells 

 profoundly arrests its development. 



If the cells win they early recharge themselves with spherules; but 

 hese are no longer eosinophile they are amphophile ; that is, they stain 

 with both eosine .and methylene-biue, and rather more -readily with 

 the latter. 



During the later portion of Stage I the eosinophile cells are aggre- 

 gating and fusing round the<chains of bacilli. 



This fusion, and the later and more complete fusion of the hyaline 

 cells is a kind of conjugation, the cells ultimately separating. 



During Stage I the hyaline cells, the .phagocytes, remain quiescent, 

 and are not attracted towards the bacilli, though they may take up 

 indifferent 'matter such as Indian ink. In the neighbourhood of a 

 healthy bacillus they appear to be paralysed. 



Stage II. Hyaline cells have now increased in numbers, and come 

 to the eosinophile cell masses surrounding a bacillus and fuse with 

 them. The eosinophile cells probably lie extended along a chain ; 

 the hyaline cells work with one object, namely, to draw the long- 

 drawn-out mass into .a ball. To this end a hyaline cell will attach 

 itself by a broad attachment, and then, by means of long filiform 

 pseudopodia stretched towards more distant parts, it will bend the 

 chain up into a close \J, rolling the eosinophile cells round itself, 

 and fusing superficially with them. The superficial fusion of 

 eosinophile cells with the hyaline cell produces violent streaming 

 movements. Other hyaline cells come and fuse with the now lobate 

 spherical and opaque mass. The impact of each successive cell acts 

 as a stimulus, causing streaming and pseudopodial movements, which 

 fade away, to be re-awakened by the arrival of a fresh cell. 



We have now a lobed mass, curiously opaque, and to take one 

 particular instance formed by the fusion of seven eosinophile cells 

 and four hyaline cells. Three eosinophile cells originally attacked 

 the chain. (It will be noted that we retain the term eosinophile 

 ceils, though the second formed spherules are at first amphophile.) 

 This fusion may persist for one to two hours. 



