': 



1893.] Chemical Changes of Sugar injected into a Vein. 181 



During the convulsive stage the pupils were contracted, although 

 still reacting to light. The respirations were greatly increased. 

 Around the mouth frothy mucus collects. The convulsions alternated 

 with periods of rest, which gradually prolonged themselves until the 

 dog seemed to be asleep. The convulsions sometimes were followed 

 by profound coma, out of which the animal could not be roused. In 

 some of the dogs the coma set in without any preliminary convulsive 

 stage. Both the convulsive and comatose state always passed off 

 when the ureters were loosed, while in some instances all the symp- 



ms disappeared of their own accord. 



10 grams of sugar per kilo, usually proved fatal to small dogs 

 during the convulsion stage, from the respirations suddenly ceasing. 

 Large dogs (of 20, or more, kilos, weight), showed only very mild 

 symptoms, even after as much as 12 grams of sugar per kilo, weight 

 were employed. 



From the order of appearance and disappearance of the symptoms 

 above alluded to, it seemed as if the sugar, by the breaking up of 

 its molecule, yielded a poison or poisons, which, on being further 

 transformed, became harmless. 



It is worthy of note that none of these symptoms occur when sugar 

 is absorbed from the intestines, no doubt for the same reason as 

 they do not occur when only small quantities of sugar are injected 

 into a vein; namely, because the intermediate products are never 

 present at any one time in sufficient quantity to produce them. 



2. The quantity of sugar that remained as sugar in the different tissues 

 of the body was estimated at various periods of time after the com- 

 pletion of its injection. 



(a.) The quantity of sugar in the blood at different periods of 

 time after its injection into the jugular vein, the ureters being 

 ligatured. 



