1893.] 



On Hepatic Glycogenesis. 



317 



It is the early rapid amylolysis which is accelerated. 



The influence of chloroform upon the structural changes in the 

 liver cells was investigated, and it was found that the disintegrative 

 changes are markedly accelerated, occurring within the first half hour. 

 This may indicate that the rapid early conversion is due to the more 

 rapid katabolic changes in the protoplasm preceding its death. 



The occurrence of glyceemia and glycosuria after the administra- 

 tion of chloroform rendered it desirable to ascertain if this accelerated 

 amylolysis occurs in the living animal under the action of the drug. 

 For this purpose, rabbits of one litter were kept on the same diet and 

 daily weighed, in order to approximate the amount of glycogen in 

 their livers. For each experiment a pair of as nearly equal weight as 

 possible were selected. One was lightly anaesthetised for three or 

 four hours, the other was not. The fallacies in this method of ex- 

 periment are fully considered. 



Such experiments seem to indicate that during life chloroform 

 accelerates hepatic amylolysis. 



z 2 



