476 Prof. D. Ferrier and Dr. W. A. Turner. [Dec. 14 r 



III. " A Record of Experiments illustrative of the Symptomato- 

 logy and Degenerations following Lesions of the Cere- 

 bellum and its Peduncles and related Structures in 

 Monkeys." By DAVID FERRIER, M.D., F.R.S., Professor of 

 Neuropathology, and W. ALDREN TURNER, M.D., Demon- 

 strator of Neuropathology, King's College, London. Re- 

 ceived November 30, 1893. 



(From the Neuropathological Laboratory, King's College, London.) 

 (Abstract.) 



This paper is the detailed record of the symptoms, temporary and 

 permanent, following total and partial extirpation of the cerebellum, 

 and section of its peduncles, and the degenerations so induced ; and 

 includes the effects of destruction of the tubercles on the posterior 

 surface of the medulla oblongata, and the degenerations resulting 

 therefrom, together with some observations on the central relations of 

 the 5th cranial nerve. The paper is illustrated by photographs taken 

 direct from the microscopical sections. Special reference is made to 

 the similar researches of Luciani and Marchi. 



The most noteworthy features of complete extirpation of the- 

 cerebellum were the extraordinary disturbances of station and loco- 

 motion, and the long-continued and apparently persistent unsteadiness 

 of the trunk and limbs on muscular effort. There were noted, also, 

 from the first, absence of tonic flexion or contracture of the limbs ; 

 retention of great and, apparently, unimpaired muscular strength, as 

 evidenced by the firmness of the grasp of the bands and feet, and the 

 agility in climbing ; and the presence, with ultimate exaggeration, of 

 the knee-jerks. There was no impairment of the general or special 

 sensibility, or disturbance of the organic functions. 



The symptoms observed after extirpation of a lateral lobe, after the 

 first tumultuous disturbance of equilibrium had passed off, were 

 similar to those observed after complete extirpation, with the impor- 

 tant difference that they were confined to the limbs on the side of 

 lesion. Except in one case, where it was only present to a slight 

 extent, there was no impulsive tendency to rotation. 



Extirpation of the middle lobe, including antero-posterior division, 

 produced, in general, the same symptoms as were observed in connex- 

 ion with removal of the whole organ and of the lateral lobe, but they 

 did not affect one side more than the other, and were more pronounced 

 in the head and trunk than in the limbs. 



The symptoms following section of the cerebellar peduncles were 

 similar to those occurring after removal of the lateral lobe, the chief 



