1894.] Changes in the Blood consequent upon Inflammation. 161 



Observations and Reports (continued). 



Ser. Bb. No. 7. Ser. C. Nos. 112, 116134. [With ac- 

 companying Maps.] 8vo. and 4to. Stockholm 1891-93. 



The Survey. 



"Washington : Weather Bureau, Department of Agriculture. 

 Monthly Weather Review. November, 1893. 4to. Washing- 

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Frederick the Great. Politische Correspondenz. Bd. XX. 8vo. 

 Berlin 1893. K. Akademie der Wissenschaften, Berlin, 



rreig (J. A.) Den Norske Nordhavs-Expedition, 1876-78. Zoologi 

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Editorial Committee of the Expedition. 



imbaut (A. A.) To adjust the Polar Axis of an Equatorial Tele- 

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The Author. 



' Note on some Changes in the Blood of the General Circula- 

 tion consequent upon certain Inflammations of acute and 

 local Character." By C. S. SHERRINGTON, M.D., F.R.S., 

 Lecturer on Physiology, St. Thomas's Hospital, Professor- 

 Superintendent of the Brown Institution, London. Re- 

 ceived December 11, 1893, Read December 14, 1893. 



[PLATE 1.] 



In result of an acute inflammatory process of even limited local 

 ctent alterations, that have been long recognised, take place in the 

 lood of the general circulation. These alterations are (1) byper- 

 losis, or increased yield of fibrin ; (2) leucocytosis, or numerical 

 icrease of leucocytes. 



Of all the phenomena of inflammation the most fundamental, apart 

 rom the local degeneration of the involved tissue, is, without doubt, 

 ibnormal exudation of intravascular fluid. The latter process must 

 produce changes in the blood in general circulation, as well as in that 

 the vascular area locally disturbed. It is these general hsemic 

 jhanges incident on local inflammation with which my experiments 



sal, especially with certain features of the inflammatory leucocy- 



sis. 



I. METHODS. 



The inflammatory lesion I have established by trauma of one or 

 other kind, induced generally by thermal means. When the seat 

 chosen for the lesion has been in the limb, the procedure has been as 

 follows. 



