consequent upon Inflammations of acute local Character. 191 



of the cell give a deeper yellow than does the nucleus itself. If, 

 as Renaut* concluded, the granules are albuminous, perhaps they 

 are of the nature of nucleo-albumin. Banvierf has suggested that 

 they are similar to the yolk-granules in ova, but I find those granules 

 for by far the most part basophil. 



In the description appended by Strieker to his well-known " Photo- 

 gramm eines farblosen Blutkorpchen " J (a coarsely-granular leuco- 

 cyte of Proteus), he states that the particles sometimes show branching 

 processes, which occasionally unite forming a network of which he 

 sees evidence in his photogram. The granules are always really 

 absolutely discrete, as shown in the phatogram appended (Plate 1, 



% 1). 



The number of granules per cell varies considerably. In the dog 

 and cat it averages between 30 and 60 ; in the latter animal I have 

 counted 78 granules and 97 granules in individual cells. In the 

 horse the number is smaller, usually 12 20, but the granules are 

 much larger (up to 4/t) approaching in size the huge mucm granules 

 discovered by Reid in the slime glands of Myxine. 



In the dog I observe four morphological varieties of this leucocyte, 

 detectable chiefly "by the granulation. 



1. The typical lar_ge cell, the body packed with granules, 30 60 in number. 



2. The cell contains, instead of granules of fairly uniform size, one or two large, 

 highly refracting masses, with a scanty number of the usual granules : I have 

 found the larger masses oxyphil, and reacting to the Lilienfeld-Monti method like 

 the usual granules. 



3. The cell contains, in addition to the highly refracting granules, a few some- 

 what smaller rounded granules <that appear in the fresh and unstained condition 

 indistinguishable from spherical vacuoles, because the substance they contain 

 hardly refracts more than the cell plasma. These also are oxyphil, like the highly 

 refracting granules, and sometimes .are amphophil. 



4. The cell is quite small ; contains a simple vesicular nucleus ; the nucleus is 

 rather large in proportion to the cell body. In the latter are coarse, highly 

 refracting -oxyphil granules, and these are distributed throughout. Dekhuysen has 

 recently pointed >out similar cells in amphibian blood. He looks upon them as the 

 young form of the coarsely granular leucocyte ; but he points out that, if I under- 

 stand him rightly, the granules are amphophil, not oxyphil. In this connexion we 

 must remember that Ehrlich has himself pointed out that the granules of his 

 typical oxyphil cell are sometimes amphophil. 



Varieties 2, 3, and 4 are, in my experience, uncommon in the 

 blood ; when 2 does ooour it seems usual for the examples of it to 

 be fairly numerous in the blood of the animal at the time ; but in 

 most dog's blood it is not to be found at all. 



* 'Archives de Physiologie Normale et Pathologique,' vol. 13, p. 649, 1881. 



t Loc. cit. 



J ' Arbeit, a. dem Path. Instit. zu Wien,' 1890. 



" Mucin Granules of Myxine," ' Journ. Physiol.,' vol. 14, p. 340, 1893. 



