Prof. C. S. Sherrington. On Changes in tlie Blood 



In cat's blood I would note three varieties of the cell. 



1. The typical large cell, with it* cell body parked with large cylindroid grains. 



2. A cell resembling in all respects the former, except that the granules are not 

 of the same highly refracting quality, and are generally smaller. These granules 

 are oxyphil, like the typical ones. Variety 2 is not so frequent as 1, but it not 

 (infrequently forms 10 per cent of all the coarsely granular leucocytes. 



3. A variety, small, and like 4 of the dog, but with granules tending to be 

 cylindroid, instead of spheroid. 



The coarsely granular leucocyte is amoeboid. Myself, from what I 

 have seen of it on the warm stage, I should incline with Lavdowski,* 

 to consider it the most actively amoeboid of all ha?mic leucocytes, were 

 it not for two difficulties. 1. At and below the ordinary temperature 

 of the room, the cell is usually less actively amoeboid than the finely 

 granular leucocyte. 2. As a rule, when fixed immediately after with- 

 drawal from the circulation the nucleus is less distorted from a 

 regular figure than is that of the majority of the finely granular 

 leucocytes, it is very usually of a simple horse-shoe shape ; now the 

 degree of irregularity of form of the nucleus may be taken as a rough 

 index of the amoeboid activity of the cell at the time of fixation. 



I have never, either in freshly drawn blood or in blood kept for a 

 time in vitro, seen an unmistakable vacuole in the coarsely granular 

 leucocyte. This stands in striking contradistinction to one's expe- 

 rience of the finely granular leucocyte. Related to this absence of 

 vacnolation appears the fact that a number of observers, including 

 Metschnikoff,t admit the want of evidence that the coarsely granular 

 haemic leucocyte is phagocytic. In my own preparations, when, after 

 being fed with bacteria in vitro, the great majority of haemic leuco- 

 cytes have ingested the bacteria (and other particles besides), the 

 coarsely granular leucocytes have not contained any. 



I think there is little doubt that, as MxillerJ says, this coarsely 

 granular cell is Ehrlich's cell with ^-granulation Ehrlich's true oxy- 

 phil cell the only question is whether his amphophil cell is not also 

 included. I gather from Ehrlich's papers, that both his cells with 

 ^-granulation (true oxyphil) and his cells with /3- granulation must 

 really be included in Wharton Jones's " coarsely granular leucocytes," 

 and therefore I have included both of them together under that head 

 in my countings. 



It is a little difficult to assign to this cell a normal percentage in 

 the blood, because it appears especially subject to numerical variation. 

 In cat's blood I have found the cell usually rather more numerous 

 than in dog's blood. Considering the two kinds of blood together, I 



' Virchow's Archiv,' TO!. 96, p. 61. 

 t ' Lemons sur 1'Innammation,' Paric, 1892. 



J "Zur Fr*ge der Blutbildung," 'Sitzungsb. d. Kai. Akad. Wien,' Abth. Ill, 

 Tol. 98, 1889. 



