198 Prof. C. S. Shrrrin-ton. On Change* in tl. 



loucocytopenia and the lyrophorrhcea occur together; but he <1<>< > 

 not find the apoplasmia of the blood noted by Heidenhain. In my 

 vjicrinn nts throughout the lenoocytopenio phase of the blood th- 

 apoplasmia of it was obvious aud steadily progressive. I have not 

 yet systematically examined the flow of lymph from the duct in my 

 form of experiment, but I have noted that the flow is sometimes 

 increased, and that the lymph may contain bfemoglobin in solution. 

 The absence of obvious increase, indeed the estimated decrease, of the 

 ratio of hyaline leucocytes to chromocytes, as well as of hyaline 

 leucocytes to granular leucocytes, indicates that any increased addition 

 of hvaline hnemic leucocytes that may occur, via the thoracic duct, is 

 out-balanced during the leucocytopenic phase by increased conversion 

 of hyaline leucocytes into granular. There is, I take it, little doubt 

 that many of the granular leucocytes are developed from the hyaline 

 form (Kolliker, Virchow, &c.) ; and an increased rate of development 

 si probable at the beginning of many forms of leucocytosis (Romer's* 

 "formativer R*iz.") 



In my experiments I have not found the leucocytopenia bear any 

 very constant relation to the fever as judged by body temperature 

 and respiratory rate. It may bear a closer relation to the process of 

 apoplasmia ; it seems to be slight when the apoplasmia is only slight. 



Second. The Leucocytotic Phase. 



The time of onset of leucocytosis varied. It became obvious in 

 something later than three-quarters of an hour after the establish- 

 ment of the local lesion. In the ligation experiments it was par- 

 ticularly late. I did not detect any very constant relation between 

 it and body-temperature or respiratory rate. 



Its duration varied. It may be prolonged for several days and 

 without much abatement. 



The anatomical details of inflammatory leucocytosis have been re- 

 cently reviewed and studied by Rieder.f I will merely point out 

 that in my observations as in his the increase in the total hsemic 

 leucocytes has been accompanied by upset of the normal numerical 

 ratio of granular to hyaline (in his observations polynucleaj- to mono- 

 nuclear) in favour of the granular leucocytes. Rieder saw the pro- 

 portion rise sometimes to 20 : 1. I have seen it rise from 6*2 : 1 to 

 19 4 : 1. 



In this feature again there is a resemblance between this form of 

 leucocytosis and that ensuing upon injection of albumoseg, bacterial 

 cultures, &c., into the circulation. Hankin and KanthackJ have 



' Virchow't Archiv, 1 1892. 

 t Op.eit. 

 I Op.eit. 



