ft i J Prof. C. S. Sherrington. On Changes in the Shod 



aqueous NaCl solution) into the jugular vein of a small dog weighing 

 I'- kilos. The countings showed the diminution of leucocytes to f:ill, 

 as Low it describes, chiefly on the polynuclear (granular) leucocytes, 

 but the ratio of coarsely granular to finely granular forms did not 

 appear indubitably altered. 



Ehrlich* suggested that the heemio leucocytes which contain his 

 a-granulatiou (the " coarsely granular" of this Note) arc derived from 

 the oxyphil cells of bone-marrow. In one form of leucocythaeraia the 

 blood seems certainly to be laden with the oxyphil marrow cells. But 

 the coarsely granular cell of the blood is not exactly an oxyphil marrow 

 cell, for the latter is, as Riederf and MuirJ have pointed out, not an 

 amoeboid cell. That the granulation is in both the cells oxyphil does 

 not establish the identity of the cells, nor even of the granulation ; a 

 variety of substances are of the eosinophilous class. Dekhuysen 

 failed to find any connexion between the haetnic leucocytes with 

 a-granulation and the oxyphil granular plasma cells and connective 

 tissue corpuscles. 



Yet Ehrlich's view is supported by several facts. Thus I find the 

 oxyphil granule* of the marrow yield the Lilienfeld-Monti reaction 

 to the same extent as the coarse granules of the haemic cell. There is, 

 too, correspondence between the shape of the granules in the cells 

 from both sources ; thus I find 



In the dog and rabbit, small spheroid granules in the coarsely 

 granular leucocyte and in the oxyphil marrow cells. 



In the horse, huge granules, spheroid, occasionally almost cuboid in the 

 cocrsely granular leucocyte and in the oxyphil marrow cells. 



In the cat, cylindroid granules in the coarsely granular leucocyte 

 and in the oxyphil marrow cell. 



But I have not been able to satisfy myself in my experiments that 

 the oxyphil cells of the marrow are affected even when Ehrlich's 

 a-granulation practically disappears from the blood. 



As the coarsely granular leucocyte is not destroyed, or altered so as 

 to escape preparation or recognition, it must be withdrawn from 

 the general circulation, either by becoming fixed in some particular 

 vascular region or by passing out of the blood vessels altogether. I 

 have not yet sufficiently examined the anatomical character of the 

 exudations to criticise these possibilities. The cellular characters 

 of the exudation have seemed to vary greatly ; sometimes many 

 cells closely resembled the coarsely granular haemic leucocyte, but 

 sometimes only a few. 



* Op. fit. 



t Op. nt. 



J ' Journ. Path, and Bact.,' vol. 1, p. 133 : 1892. 



' Verhandl. der Anat. Geuellachaft,' 1892. ' Anat. Anxeiger.' 



