106 Prof. C. S. Sherrington. On CJtaityes in the lUood 



greatly reduce the number of these cells. I judge so from tlu-ir 

 practical absence from the blood of three animals admitted into the 

 Brown Institute in a destitute and starving state. Two of these 

 animals did not recover, and autopsy revealed nothing but evidence 

 I' starvation, and slighter cases of the kind are not infrequently ad- 

 mitted at the Institution. I have also found the cell abnormally 

 scarce in the blood at a late stage after thyroidectomy. The cell was 

 scarce in the blood of a bitch which had thrown puppies twenty-four 

 hours previously, though her temperature was normal. In a dog with 

 a large subcutaneous abscess and in a horse with submaxillary 

 abscess, I had great difficulty in finding any coarsely granular leuco- 

 cytes, bat the last two examples come under the same category as my 

 own experiments, except that the local inflammatory conditions were 

 subacute. 



Canon* has concluded that the number of eosinophilons cells 

 in the blood is increased in all diseases of skin. In a dog admitted 

 with a severe scald of the back I found the bloud almost destitute of 

 these cells (coarsely granular), and it remained so for the first four 

 dnys after admission. In the experiments in which skin was involved 

 in the lesion (Series I) the diminution of the cells was as marked as 

 in experiments where skin was not involved. Felsenf noticed in 

 three cases of croupous pneumonia that at the height of the " fever " 

 eosinophilous cells seemed absent from the blood. Noorden,J on the 

 other hand, has seen a great increase in the number of eosinophilous 

 cells in bronchial asthma at the time of the attack. 



Hankin has made an interesting observation that the blood clots 

 rapidly when the coarsely granular cell is scanty in the blood. I have 

 pointed out|| that the coarsely granular cell does not initiate clotting 

 in dog's blood. In the present experiments the blood, at a time when 

 almost (perhaps actually) free from coarsely granular leucocytes, 

 clotted very speedily and firmly, as is well known for blood in inflam- 

 mation. 



DESCRIPTION OF PLATE 1. 



I wish here to thank very heartily Mr. A. F. S. Kent, to whose skill is due the 

 success of the photoiuicrograms appended in illustration of some points described 

 in the text. 



Fio. 1. " Coarsely granular " hsemic leucocyte of cat. Photographed while living, 

 x 1000. The usual horseshoe shaped nucleus and the cylindroid granules 

 are obvious. Zeiss apochromatic 2 mm. 



* ' Deutsche Medic. Woohen.,' p. 206, 1892. 



t ' Archiv f. Kinderheilkunde,' vol. 15, p. 78, 1892. 



I ' Zeits. f. klin. Med.,' vol. 20, Part II, 1892. 



' Centralblatt f. Bacteriol.,' voL 12, p. 777, 1892. 



II Loc. di. 



