424 Dr. L. Bruntoii and Mr. S. Delepine. Changes [Apr. 2fJ, 



VII. ** Report on some of the Changes produced on Liver Cells 

 by the Action of some Organic and Inorganic Compounds." 

 By T. LAUDER BRUXTOX, M.D., F.R.S., and S. DELEPINE, 

 M.B. Received March 14, 18 1 J4. 



We have, on a former occasion, given an account of the scope of tJie 

 investigation, and of the methods used, of some preliminary observations* 

 which we have found it necessary to make. 



Briefly speaking, our object was to ascertain the action of drugs on 

 the cells of the liver and to connect, if possible, the changes in the 

 cells with the physiological action of the drugs and their chemical 

 structure. 



Certain drugs were selected by one of us (Brunton) as being 

 most suitable for this investigation. These drugs were the follow- 

 ing : 



Benzene C 6 Hj'H 



Phenol C 6 H 5 -OH 



Toluene C 6 H S -CH, 



Aniline C,H 5 -NH 2 



fCH,(l) 

 Toluylene diamine (meta) CH 3 < NH 2 (3) 



INH, (4) 



Chrysophauic acid Ci H 4 O4 



Pilocarpine nitrate 



Atropine ( 



Ammonia Nil 



Ammonium chloride NH 4 'C1 



Nitric acid HNO, 



Sodium iodide Nal 



We have recorded the various appearances which we have observed as 

 the result of the purely physiological stimulation of the liver produced by 

 the ingestion and digestion of a meal, and have noticed that the most 

 important changes indicating various states of activity were : 



1. The size of the cells. 



2. The distinctness of the mitoma and of the cellular cleavage. 



sped ing the structures that distinguish Lepidodcndron from Lepidophloios. Some 

 trust to the several forms of the sections of the leaves, leaf-scars and leaf- 

 cushions ; others to the upward or downward directions taken by the elongated 

 portions of the leaves. In fact the question demands a more critical and conclu- 

 sive investigation than it has yet received. Note, April 19, 1891. 



' Roy. Soc. Proc.,' Oct. 22, 1891, vol. 50, p. 209, and Paper placed in the 

 Archives. 





