426 Dr. L. Brunton and Mr. S. Delepine. Changes [Apr. LV>. 



B. There were very few psorosperms in the liver, which was of 

 small size. 



Cells small, or of medium size. 



Outlines of the cells and the mitoma much clearer than normal. 



Meshes of the mitoma pretty large ; some grouped round the lateral 

 bile canaliculi. 



Main and lateral bile canaliculi very distinct and very large. 



Glycogen reaction normal, i.e., doubtful and diffuse. Only slight 

 traces of sugar could be obtained in 24 hrs. after death. 



Iron reaction less marked than normal. 



C. The state of the mitoma of the cells, and the amount of iron in- 

 dicate secretory activity. 



This may be taken as a type of liver in a state of secretory activity. 



Action of Pilocarpine on a Fasting Liver. 



A. Last food given about 26 hrs. before death, the food not eaten 

 being removed 17 hrs. before death. (This is an exception to the rule 

 generally followed.) 



Subcutaneous injection of ^ grain of pilocarpine (a little more than 

 gram O03) was given 1 hr. 30 mins. before death. 



B. Liver apparently healthy. 



Cells large and swollen looking. 



Outline of the cells and the cellular mitoma extremely distinct. 



Meshes of the mitoma very large. 



Bile canaliculi large and distinct. 



C. These changes correspond to those observed in an active liver, 

 and may be taken to indicate secretory activity. 



Action of Pilocarpine on a Fed Liver. 



A. Last food given 7 hrs. before death. 



Death blow 2 hrs. 43 mins. after a first subcutaneous injection of 

 grain (gram 0'042) of pilocarpine (a second injection of the same 

 quantity having been given 38 mins. before death). 



B. Liver moderately diseased, containing a few large psorospermic 

 masses, and being somewhat above the average size. 

 Cells generally large but variable in size. 



Outlines of cells and the mitoma even more distinct than normal. 

 Meshes of the mitoma large, specially round the nuclei. 

 Bile canaliculi indistinct. 



