1< S 94.] produced on Liver Cells by various Compounds. 421 



Glycogen reaction about normal, slightly diminished. 

 Sugar reaction, 24 hrs. post m-ort., slightly diminished. 

 Iron reaction much diminished, both in the diffuse and in the 

 granular form. 



C. The changes produced in the fed liver correspond closely with 

 those observed in the fasting organ, and may be taken as typical of 

 secretory activity. 



Action of Toluene on a Fasting Liver. 



A. Last meal 31 hrs. before death. 



Hectal injection of 1 gram (15'5 grains) of toluene suspended in 

 10 c.c. of thin mucilage, 56 mins. before death. 



B. Liver of moderate size, with pretty abundant psorosperinic 

 lesions. 



Cells small and medium sized. 



Outline and mitoma clear, much clearer than normal. 



A few large meshes, specially grouped round the nucleus. 



Bile canaliculi not generally distinct, when distinct very narrow. 



Glycogen reaction distinct round the hepatic vein, and therefore 

 increased. 



Sugar formed in 24 hrs. post mort., much more abundant than 

 normal. 



Iron reaction almost absent, and therefore less than normal. 



C. The action resembles somewhat that of pilocarpine, but differs 

 from it on account of the increase of glycogen. 



Action of Toluene on the Fasting Liver. 



A. Last meal 20 hrs. before death. 



Subcutaneous injection of about 0'06 gram (i.e., = about 0'9 grain) 

 of pure toluene 4 hrs. 45 mins. before death. 



B. Liver apparently not diseased. 



Cells pretty large. 



Outline of cells and mitoma more distinct than normal. 



Meshes of mitoma a little larger than normal. 



Bile canaliculi very distinct. 



Blood capillaries rather congested. 



C. There is stimulation of the cells resembling, to a certain extent, 

 that produced by pilocarpine, but much less marked. 



