428 Dr. L. Brunton and Mr. S. Delepine. Changes [A}> 



Action of Toluene on a Fed Liver. 



A. Last food 8 hrs. before death. 



Subcutaneous injection of about 0'06 gram of pure toluene 4 hrs. 

 .">:' mins. before death. 



B. Liver apparently not diseased. 



Cells rather small. 



Outline of cells and mitoma distinct. 



Meshes large. 



Bile canaliculi distinct here and there. 



Blood capillaries excessively congested. 



C. With the exception of the size of the blood capillaries, there is 

 no very marked departure from the normal. 



Action of Benzol on a Starving Liver. 



A. Last meal 31 hrs. before death (a few very small bits of carrots 

 were unfortunately left within reach of the animal during injection). 



Rectal injection of 1'15 gram (i.e. 17'8 grains) of benzol, suspended 

 in 10 c.c. of thin mucilage 2 hrs. 30 mins. before death. 



Subcutaneous injection of about 0'5 c.c. of pure benzol 2 hrs. 5 mins. 

 before death. 



B. Liver large, with abundant psorospermic lesions. 



Cells pretty large. 



Mitoma and outline distinct, much more so than normal. 



Meshes of mitoma large. 



Bile canaliculi very distinct, main canaliculi in portal zone. 



Glycogen reaction very slightly increased, diffuse. 



Sugar formed in 24 hrs. post mart., very little, about normal. 



Iron reaction very slight, normal ? 



C. The action is very similar to that of pilocarpine in every j 

 respect. 



Note. In this case it is possible that the munching of a few bits of 

 carrot may have stimulated the liver ; but the quantity so ingested was 

 very small, and probably had no distinct effect. 



Action of Benzol on a Fed Liver. 



A. Last meal 8 hrs. 34 mins. before death. 

 Rectal injection of 1 gram of benzol, suspended in 10 c.c. of thin 

 mucilage, 1 hr. before death. 





