L894.] produced on Liver Cells by various Compounds. 429 



B. Liver very large, the largest observed. Psorospermic lesions 

 in moderate amount. 



Cells very large, swollen-looking. 



Mi low a and outline of cells very clear. 



Meshes of mitoma large, specially round the nucleus. 



Bile canaliculi indistinct. 



Glycogen reaction very abundant round hepatic vein, somewhat 

 liffuse elsewhere. 



Sugar produced post mort. in 24 hrs. less than normal. 



Iron reaction much diminished. 



C. This action resembles closely that of pilocarpine. 



Action of Sodium Iodide on a Fasting Liver. 



A. Last meal 25 hrs. before death. 



Rectal injection of 1'75 grams (i.e., about 27 grains) of iodide of 

 sodium dissolved in 10 c.c. of water 1 hr. before death. 



B. Liver medium sized, with very few psorospermic lesions. 



Cells medium sized. 



Mitoma and outline of cells pretty distinct. 



Meshes of mitoma generally medium, sized, some very large round the 

 nuclei. 



Bile canaliculi distinct at places but very small. 



Glycogen, slight amount round the hepatic vein. 



Sugar formed in 24 hrs. post mort., the largest quantity produced 

 except after toluylene diamine. 



Iron reaction very indistinct, less than normal. 



C. Resembles pilocarpine except as regards the tendency of accu- 

 mlation of glycogen. 



Action of Sodium Iodide on a Fed Liver. 



A. Last meal 7 hrs. 40 mins. before death. 



Rectal injection of 2 grams (31 grains) of sodium iodide dissolved in 

 10 c.c. of water 42 mins. before death. 



B. Liver larger than normal, psorospermic lesions very few. 

 Cells irregular, some very large, some small, angular. 

 Mitoma and outline of cells very distinct, more so than normal. 

 Meshes of the mitoma large, some very large round nuclei. 

 Bile canaliculi indistinct. 

 Glt/cogen, largest amount seen in any liver. 



Siigar formed in 24 hrs. post mort., large amount, perhaps a little 

 more than normal. 



