430 Dr. L. Bnmton aiid Mr. S. Del6pine. Changes [Apr. L'I'.. 

 Iron reaction very slight, less than normal. 



C. Action resembles that of pilocurpine, bat in addition there is a 

 marked tendency to accumulation of glycogen. 



Action of Chrysophanic Acid on a Fasting Liver. 



A. Last meal 28 hrs. before death (animal allowed to eat a small bit 

 of carrot during the injection). 



Rectal injection of O'l gram (i.e., about \\ grains) of chrysophanic 

 acid suspended in 10 c.c. of thin mucilage 2 hrs. 23 mind, before 

 death. 



B. Inver moderately large with very few psorospermic lesions. 

 Cells generally small or medium sized. 



Outline of cells and mitoma clear, much more so than normal. 

 Meshes of mitoma generally small, a few large ones round the 

 nucleus. 



It He canaliculi, main and lateral distinct. 

 Glycogen reaction increased, slight round the hepatic veins. 

 Sugar formed in 24 hrs. post mort., more abundant than normal. 

 Iron reaction very slight, less than normal. 



C. This action resembles that of pilocarpine. 



Action of Ammonium Chloride on a Fasting Liver. 



A. Last meal 28 hrs. before death. 

 Rectal injection of 1 gram (15'5 grains) of ammonium chloride dis- 

 solved in 10 c.c. of water 2 hrs. before death. 



B. Liver small, with very few psorospermic lesions. 



Cells large. 



Mitoma and outline of cells pretty distinct. 



Meshes of mitoma large in some places. 



Bile canaliculi generally indistinct. 



Glycogen doubtful diffuse reaction (normal). 



Sugar formed in 24 hrs. post mort., very little (normal). 



Iron reaction slight, about normal. 



C. Stimulation of the cells is indicated by the changes in the 

 mitoma, similar to, but not so marked, as those produced by 

 pilocarpine. 



Action of Ammonium Chloride on a Fed Liver. 

 A. Last meal 9 hrs. 20 mins. before death. 



