1894.] produced on Liver Cells by various Compounds. 431 



Rectal injection of 1 gram of chloride of ammonium in 10 c.c. of 

 water (sp. gr. 1025) 1 hr. 5 mins. before death. 



B. Liver large, with few psorospermic lesions. 

 Cells large, looking swollen. 



Mitoma and outline of cells very distinct (more than normal). 

 Meshes of mitoma large round the nucleus. 

 Bile canaliculi narrow, distinct only in portal zone. 

 Glycogen abundant, chiefly round the hepatic (more than normal). 

 Sugar formed in 24 hrs. post mort., large amount (a little above 

 lormal). 

 Iron reaction entirely absent (much less than normal), 



C. This is a stimulating action similar to that of pilocai'pine, but 

 there seems to be in addition a tendency to the accumulation of 

 ylycogen. 



Action of Toluylene Diamine (Meta) on a Fasting Liver. 



A. Last meal 29 hrs. before death. 4 hrs. 10 mins. before death, 

 gram 0'5 (grains 7f ), suspended in 10 c.c. of mucilage, injected per 

 rectum. 3 hrs. 36 mins. before death, gram 0'06 (i.e., 1 grain), 

 dissolved in 5 drops of benzol injected subcutaneously. 20 mins. 

 before death, gram 0'06 given in a slice of carrot. 



B. Liver large, with pretty abundant psorospermic lesions. 



Cells generally large, but variable in size. 



Mitoma and outside of cells not very distinct, but clearer than 

 normal. 



Meshes of mitoma medium sized, larger than normal. 



Bile canaliculi indistinct. 



Glycogen reaction well marked round the hepatic vein, i.e., more 

 marked than normal. 



Sugar formed in 24 hrs. post mort. more abundant than normal. 



Iron reaction almost entirely absent. 



C. The action of toluylene diamine in this case resembles that of 

 pilocarpine, except as regards the production of sugar post mort. 



Action of Toluylene Diamine (Meta) on a Fasting Liver. 



A. Animal killed 24 hrs. after its last meal. A little under gram 

 0'5 (=7 grains), finely divided, and suspended in 10 c.c. of water, 

 injected per rectum 2 hrs. 13 mins. before death. 



B. Liver moderately large, a pretty large number of psorospermic 

 lesions were present. 

 Cells generally large. 



