432 Dr. L. Brunton sunl Mr. S. Del^pine. Changes [Apr. L'i5, 



l[if<>ma and outline of cells more distinct than normal. 

 Meshes large. 



Bile canaliculi where distinct small, but generally indistinct. 

 Glycogen reaction increased immediately round the hepatic vein. 

 Post-mortem production t of sugar in 24 hours more marked than in 

 any other case. 



Iron reaction almost absent. 



C. With the exception of the post mart, production of sugar this 

 action resembles closely that of pilocarpine. 



Action of Toluylene Diamine (Meta) on a Liver immediately after the 



taking of Food. 



A. Last ordinary meal 25 hrs. before death ; 17 hrs. 30 mins. before 

 death the animal was given carrots with gram O09 of toluylene diamine ; 

 1 hr. 30 mins. before death a new dose of O06 gram of toluylei 

 diamine was given with 10 grams of carrota by the mouth. 



B. Liver pretty large, psorospermic lesions pretty abundant. 



Cells large. 



3/7fo;na and outline very distinct. 



Meshes large, chiefly round the nucleus. 



Bile canaliculi generally indistinct ; where distinct, small. 



Glycogen reaction slight round the hepatic vein (about normal). 



Sugar formed in 24 hrs. post mort., more abundant than normal. 



Iron reaction entirely absent, normal. 



C. Action similar to that of pilocarpine, with the exception of the 

 production of sugar post mort. 



Action of Nitric Acid on a Starving Liver. 



A. Last meal 25 hrs. before death. 

 Rectal injection of 1 c.c. of nitric acid diluted in 10 c.c. of water 

 (sp. gr. 1024), 1 hr. 15 mins. before death. 



B. Liver large, with few psorospermic lesions. 

 Cells small or medium-sized. 

 M^itoma and outline of cells not very distinct, but more so than, 

 normal. 



Meshes of mitoma distinctly larger than normal. 



Bile canaliculi, main very distinct, lateral often distinct. 



Glycogen reaction doubtful, diffuse, normal. 



Sugar formed post mort. in 24 hrs., very small amount, about normal. 



Iron reaction very slight, less than normal. 



C. The action resembles much that of pilocarpine. 



